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Journals Biological Chemistry Volume 392 Issue 12

Cathepsin W is exclusively expressed in immune cells, and a novel isoform was identified previously. To characterize the expression pattern of the wildtype and isoform Ins10, specific polymerase chain reaction assays were generated and used to study respective transcript levels in peripheral blood cells and gastric biopsies in healthy subjects. The wildtype-encoding transcript levels were 3- and 9-fold higher in mucosal samples and peripheral immune cells, respectively ( p <0.05). The predominant expression of wildtype form by infiltrating immune cells was confirmed in 116 patients with gastroesophageal reflux disease and 27 reflux-negative individuals demonstrating that cathepsin W expression is not altered in this disease.

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Expression pattern of cathepsin W isoforms in peripheral blood and gastroesophageal mucosa of patients with gastroesophageal reflux disease

More Info
  • Publisher Walter de Gruyter
  • Copyright ©2011 by Walter de Gruyter Berlin Boston
  • Subject Proteolysis
  • ISSN 1431-6730
  • eISSN 1437-4315
  • D.O.I. 10.1515/BC.2011.192
  • Publisher site Get PDF  

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