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Chelation of Ambilhar with Calcium and Magnesium

Chelation of Ambilhar with Calcium and Magnesium Introduction Earlier studies on Ambilhar (niridazole or nitrothiazole) demonstrated its direct effect on body iron. Salah et al proved that the drug decreased serum as well as liver iron. At' the same time the drug increased urinary iron output. Later, Abdel Aziz et al (2) showed that the drug chelated body iron. The side effects of Ambilhar on the central nervous system (3) lead us to investigate its effects on some other body minerals. The earlier studies of Fitzgerald (4) arid Flink (5) showed that magnesium deficiency resulted in muscle tremor, twitching, convulsions and delirium. These symptoms were also observed in our hospital patients treated with Ambilhar for buiarziasis. J. Clin. Chem. Clin. Biochem. / Vol. 16,1978 / No. 1 The aim of this study is to investigate the effects of Ambilhar on body calcium, magnesium and phosphorus. Material and Methods In vivo investigations Twenty normal rabbits of the domestic type found in the Middle East, with an average body weight of 1.5-2 kg, were used for our study. They were fed with ordinary fresh vegetables collected for animals in the college animal house. They were classified into two equal groups. Group A were used as the control http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry and Laboratory Medicine de Gruyter

Chelation of Ambilhar with Calcium and Magnesium

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Publisher
de Gruyter
Copyright
Copyright © 2009 Walter de Gruyter
ISSN
1434-6621
eISSN
1437-4331
DOI
10.1515/cclm.1978.16.1.11
Publisher site
See Article on Publisher Site

Abstract

Introduction Earlier studies on Ambilhar (niridazole or nitrothiazole) demonstrated its direct effect on body iron. Salah et al proved that the drug decreased serum as well as liver iron. At' the same time the drug increased urinary iron output. Later, Abdel Aziz et al (2) showed that the drug chelated body iron. The side effects of Ambilhar on the central nervous system (3) lead us to investigate its effects on some other body minerals. The earlier studies of Fitzgerald (4) arid Flink (5) showed that magnesium deficiency resulted in muscle tremor, twitching, convulsions and delirium. These symptoms were also observed in our hospital patients treated with Ambilhar for buiarziasis. J. Clin. Chem. Clin. Biochem. / Vol. 16,1978 / No. 1 The aim of this study is to investigate the effects of Ambilhar on body calcium, magnesium and phosphorus. Material and Methods In vivo investigations Twenty normal rabbits of the domestic type found in the Middle East, with an average body weight of 1.5-2 kg, were used for our study. They were fed with ordinary fresh vegetables collected for animals in the college animal house. They were classified into two equal groups. Group A were used as the control

Journal

Clinical Chemistry and Laboratory Medicine – de Gruyter

Published: Jan 1, 1978

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