Utilizing Microarrays of Bacterial Genes O. Colin Stine, Ph.D. Department of Epidemiology and Preventative Medicine University of Maryland School of Medicine 108 N. Greene St. Suite 119 Baltimore, Maryland 21201 1-410-706-1607 ostin001 @umaryland .edu Microarrays can be employed to identify bacteria, changes in their genomes and the expression of their genes. Bacterial genomes are very small and simple compared to the human genome. Nevertheless there is enormous genetic diversity among bacterial genomes. The diversity is manifest in two ways. First, some genes are in found in many species. These genes exhibit small changes in their sequences and as the species get further apart the proportion of differences increases. Second, some species have genes that are not found in a second species This is expected for organisms that manage to inhabit every niche imaginable. Bacteria in different habitats will need different sets of genes to survive and their small size and need for rapid growth selects for discarding unnecessary genes, Bacteria are found everywhere. In ourselves and other animals, bacteria are normally present in our nose and mouth, skin, and intestines. In our world, bacteria inhabit food, drinking water, soil, aquifers, streams, rivers, beaches, oceans, sewage wastes, hot springs,
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Utilizing microarrays of bacterial genes
Stine, O. Colin
Follow ACM SIGBIO Newsletter
, Volume 21 (1)
Association for Computing Machinery – Apr 1, 2001
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