The Biology Workbench Shankar Subramaniam University of California, san Diego San Diego Supercomputer Center Shanker@sdsc.edu Eric Jakobsson University of Illinois, Urbana-Champaign National Center for Supercoml:)utingApplications jake@ncsa.uiuc..edu 1. INTRODUCTION The Biology Workbench (workbench.sdsc.edu) is a point-andclick Web-based environment that makes cutting-edge bioinformatics capabilities accessible to all scientists, students, and teachers. The term "bioinformatics" is defined in different ways by some different people. In our context, we mean the array of computational techniques that have been developed to construct meaning from information about the sequences of amino acids in proteins and bases in nucleic acids. The components of bioinforrnatics are databases, and computer programs that analyze the contents of those databases for patterns and similarities, in the service of posing and answering biological questions. The essence of the Biology Workbench is the construction of a user interface and a software architecture that integrates the databases and the analysis programs in a common virtual environment on the Web. In this environment, all components of the system appear as though they were all components of the same program on the user's machine, with "point-and-click" movement back and forth between the components. In fact the components are residing on a supercomputer (originally at
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