516810 New51etter pa9e 11 Recent 7a1k5 at 5tanf0rd Un1ver51ty 0n A1M DA7E: Fe6ruary 24, 1984 5PEAKER: 8en Ku1per5, Department 0f Mathemat1c5 7uft5 Un1ver51ty 70P1C: 5tudy1n9 Expert5 t0 Learn A60ut Qua11tat1ve Cau5a1 Rea50n1n9 11ke1y hyp0the5e5 that acc0unt f0r a 91ven 5et 0f f1nd1n95. 7h15 ta1k w111 pre5ent the techn14ue5 1t u5e5 t0 f0rm and 5c0re d1a9n05t1c hyp0the5e5. Part1cu1ar empha515 w111 6e p1aced 0n de5cr161n9 h0w 1nf0rmat10n a60ut the funct10na1 f0rm 0f cau5a1 kn0w1ed9e can 6e c0m61ned w1th 5par5e pr06a6111ty data t0 60und the pr06a6111ty 0f d1a9n05t1c hyp0the5e5. A150, the 5earch techn14ue u5ed t0 9enerate mu1t1p1e d15ea5e hyp0the5e5 w111 6e pre5ented. A65tract 8y ana1y21n9 a ver6at1m pr0t0c01 0f an expert ¢5 exp1anat10n we can der1ve c0n5tra1nt5 0n the c0nceptua1 framew0rk u5ed 6y human expert5 f0r cau5a1 rea50n1n9 1n med1c1ne. We u5e the5e c0n5tra1nt5, a10n9 w1th text600k de5cr1pt10n5 0f phy5101091ca1 mechan15m5 and the c0mputat10na1 re4u1rement5 0f 5ucce55fu1 perf0rmance, t0 pr0p05e a m0de1 0f 4ua11tat1ve cau5a1 rea50n1n9. 0ne 1mp0rtant de519n dec1510n 1n the m0de1 15 the 5e1ect10n 0f the "env1510nment ¢ ¢ ver510n 0f cau5a1 rea50n1n9 rather than a ver510n 6a5ed 0n ¢ ¢cau5a1 11nk5. ¢ ¢ 7he env1510nment pr0ce55 perf0rm5 a 4ua11tat1ve 51mu1at10n, 5tart1n9 w1th a de5cr1pt10n 0f the 5tructure 0f a mechan15m and pred1ct1n9 1t5 6ehav10r. 7he 4ua11tat1ve cau5a1 rea50n1n9 a190r1thm 15 a 5tep t0ward 5ec0nd-9enerat10n med1ca1 d1a9n0515 Pr09ram5 that under5tand h0w the mechan15m5 0f the 60dy w0rk. 7he pr0t0c01 ana1y515 meth0d 15 a kn0w1ed9e ac4u151t10n techn14ue f0r determ1n1n9 the c0nceptua1 framew0rk 0f new type5 0f kn0w1ed9e 1n an expert 5y5tem, pr10r t0 ac4u1r1n9 1ar9e am0unt5 0f d0ma1n-5pec1f1c kn0w1ed9e. 7he 4ua11tat1ve cau5a1 rea50n1n9 a190r1thm ha5 6een 1mp1emented and te5ted 0n med1ca1 and n0n-med1ca1 examp1e5. 1t w111 6e the c0re 0f RENAL, a new expert 5y5tem f0r d1a9n0515 1n nephr0109y, that we are n0w deve10p1n9. M0LECULAR C0MPU7ER5 * -~ $~ -)6 M01ecu1ar C0mputer5, Part 2 M1chae1 C0nrad Department5 0f C0mputer 5c1ence and 810109y Wayne 5tate Un1ver51ty Detr01t, M1 48202 A65tract Pr09ramma6111ty, ev01va6111ty, and eff1c1ency are t1ed t09ether 6y a trade0ff pr1nc1p1e wh1ch may exp1a1n the rad1ca11y d1fferent c0mputat10na1 capa6111t1e5 0f 6101091ca1 5y5tem5 and d191ta1 c0mputer5. DA7E: Fe6 3, 1984 5PEAKER: 6re9 C00per, 5tanf0rd Un1ver51ty 70P1C: NE570R: A C0mputer-8a5ed Med1ca1 D1a9n05t1c A1d wh1ch 1nte9rate5 Cau5a1 and Pr06a61115t1c Kn0w1ed9e A65tract NE570R 15 a c0mputer pr09ram that a1d5 phy51c1an5 1n d1a9n051n9 the caU5e 0f hyperca1cem1a 1n pat1ent. 1t 15 a f0rm1 pr06a61115t1c 5y5tem wh1ch u5e5 cau5a11y 5tructured pr06a61115t1c kn0w1ed9e t0 determ1ne the m05t 7h15 paper wa5 extracted 6y R0y Rada fr0m M1chae1 C0nrad ¢5 ¢ ¢De519n Pr1nc1p1e5 f0r a M01ecu1ar C0mputer ¢ ¢. ¢ ¢De519n Pr1nc1p1e5 f0r a M01ecu1ar C0mputer ¢ ¢ wa5 the Keyn0te Addre55 pre5ented at the C0nference 0n Chem1ca1/y-8a5ed C0mputer 0e519n, 5p0n50red 6y the Nat10na1 5c1ence F0undat10n and the Crump 1n5t1tute f0r Med1ca1 En91neer1n9, 5anta M0n1ca, CA. 0ct06er 24-29, 1983. ¢ ¢M01ecu1ar C0mputer5, Part 2 ¢ ¢ c0nt1nue5 the theme deve10ped 6y M1chae1 1n h15 art1c1e ent1t1ed ¢ ¢810med1ca1 C0mput1n9--A New 5c1ence ¢ ¢ that appeared 1n 5/6810 New51etter, 6, 4 p 2-4.

/lp/association-for-computing-machinery/recent-talks-at-stanford-university-on-aim-Aa4Foo0jbN