High-throughput DNA Chips for Efficient Screening and Analysis Deval A. Lashkari & James Gilmore Genometrix, Inc., 3608 Research Forest Drive, The Woodlands, TX 77380 Dlashkari@Genometrix.com, jgilmore@Genometrix.com I. Introduction DNA microchips have established themselves as the latest technology in the pharmaceutical industry's drug development toolbox. The DNA chips have already had a significant impact in the field of genomics (Iyer, 1999), which is described as the broad uncovering and understanding of the workings of the entire human genome. The human genome and its construction is immensely complex, to say the least, and understanding the genome will essentially provide a greater comprehension of the molecular and genetic basis of disease. Deciphering the genome is a daunting undertaking that would be impossible without the development of new technologies that enable faster, better, and smarter analysis of the genome. Researchers need to link the actual DNA text (a gene) with its meaning (the gene's function) and they need to do this for the -100,000 genes in the human genome. With the development of high-throughput detection and analysis methods, associating function to specific genes and sequences is a reality. One such method, DNA chips, permit this broad view across the entire genomic landscape.
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High-throughput DNA chips for efficient screening and analysis
Lashkari, Deval A.; Gilmore, James
Follow ACM SIGBIO Newsletter
, Volume 19 (2)
Association for Computing Machinery – Aug 1, 1999
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