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Journals ACM SIGEVOlution Volume 5 Issue 4

Beyond Biology Designing a New Mechanism for Self-Replication and Evolution at the Nanoscale Rebecca Schulman, Chemical and Biomolecular Engineering, Johns Hopkins University, rschulm3@jhu.edu As biology demonstrates, evolutionary algorithms are an extraordinarily powerful way to design complex nanoscale systems. While we can harness the biological apparatus for replicating and selecting DNA sequences to evolve enzymes and to some extent, organisms, we would like to build replication machinery that would allow us to evolve designs for a much wider variety of materials and systems. Here we describe work that uses techniques from the new eld of structural DNA nanotechnology to modularly design nanoscale components that together can be assembled into a system for self-replicating a new form of chemical information or genome, and thus for evolving a new type of chemical sequence. These features are essential to the capacity of biology for self-replication, self-healing and metamorphosis. By having similar control over molecular synthesis and nanoscale geometry in synthetic systems, it should be possible to achieve these features as well as many others in synthetic materials. Biology ™s sophisticated architecture is the product of the Darwinian evolution of a genomic sequence, an organism ™s program for growth and function. Evolution is

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Beyond biology: designing a new mechanism for self-replication and evolution at the nanoscale

Schulman, Rebecca
ACM SIGEVOlution , Volume 5 (4)
Association for Computing Machinery – Nov 1, 2011

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