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Virus-Induced Chromosome Abnormalities

Virus-Induced Chromosome Abnormalities In the last ten years, viruses have taken their place with irradiation and chemicals as environmental agents that are capable of producing cytogen­ etic effects. Several types of chromosome change can be produced by virus­ cell interaction. The biologic significance of the induced chromosome change is not clear at the present time, but is of potential importance in cell death, carcinogenesis, aging, teratogenesis, and somatic and germ cell muta­ tions. In the p r esent paper, types of chromosome change resulting from virus­ cell interaction will be described, the possible mechanisms of virus-induced defects will be enumerated, and a discussion of the potential significance of the lesions will be offered. CYTOGENETIC CHANGES INDUCED BY VIRUS-CELL INTERACTION Before describing virus-associated chromosomal lesions, a classification and definition of various types of defects will b e presented . Unfortnnately, no single classification of chromosome abnormalities is accepted by all au­ thors. This leads to some confusion and redundancy. The characteristic adopted to classify chromosomal abnormalities has frequently depended on the type of study under way and the information sought. One of the main characteristics used to classify chromosome breaks has been whether one or both of the two chromatids of the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Microbiology Annual Reviews

Virus-Induced Chromosome Abnormalities

Nichols, W W
Annual Review of Microbiology , Volume 24 (1) – Oct 1, 1970
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Publisher
Annual Reviews
Copyright
Copyright 1970 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4227
eISSN
1545-3251
DOI
10.1146/annurev.mi.24.100170.002403
pmid
4929655
Publisher site
See Article on Publisher Site

Abstract

In the last ten years, viruses have taken their place with irradiation and chemicals as environmental agents that are capable of producing cytogen­ etic effects. Several types of chromosome change can be produced by virus­ cell interaction. The biologic significance of the induced chromosome change is not clear at the present time, but is of potential importance in cell death, carcinogenesis, aging, teratogenesis, and somatic and germ cell muta­ tions. In the p r esent paper, types of chromosome change resulting from virus­ cell interaction will be described, the possible mechanisms of virus-induced defects will be enumerated, and a discussion of the potential significance of the lesions will be offered. CYTOGENETIC CHANGES INDUCED BY VIRUS-CELL INTERACTION Before describing virus-associated chromosomal lesions, a classification and definition of various types of defects will b e presented . Unfortnnately, no single classification of chromosome abnormalities is accepted by all au­ thors. This leads to some confusion and redundancy. The characteristic adopted to classify chromosomal abnormalities has frequently depended on the type of study under way and the information sought. One of the main characteristics used to classify chromosome breaks has been whether one or both of the two chromatids of the

Journal

Annual Review of Microbiology – Annual Reviews

Published: Oct 1, 1970

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