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- Publisher
- Annual Reviews
- Copyright
- Copyright © 2014 by Annual Reviews. All rights reserved
- ISSN
- 0199-9885
- eISSN
- 1545-4312
- DOI
- 10.1146/annurev-nutr-071813-105654
- pmid
- 25033061
- Publisher site
- See Article on Publisher Site
Abstract
Hydrogen sulfide (H 2 S) has emerged as an important signaling molecule with beneficial effects on various cellular processes affecting, for example, cardiovascular and neurological functions. The physiological importance of H 2 S is motivating efforts to develop strategies for modulating its levels. However, advancement in the field of H 2 S-based therapeutics is hampered by fundamental gaps in our knowledge of how H 2 S is regulated, its mechanism of action, and its molecular targets. This review provides an overview of sulfur metabolism; describes recent progress that has shed light on the mechanism of H 2 S as a signaling molecule; and examines nutritional regulation of sulfur metabolism, which pertains to health and disease.
Journal
Annual Review of Nutrition – Annual Reviews
Published: Jul 17, 2014