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Neuropeptide Y-Related Peptides and their Receptors--Are the Receptors Potential Therapeutic Drug Targets?

Neuropeptide Y-Related Peptides and their Receptors--Are the Receptors Potential Therapeutic Drug... A decade has passed since the discovery of neuropeptide Y (also known as neuropeptide ty rosine or NPY) by Tatemoto &Mutt (1, 2). This 36-amino-acid peptide, arguably the most abundant and widely distributed of neuropeptides discovered to date, has stimulated several thousand scientific publications . NPY seems t o fulfill the main neurotransmitter criteria, since it i s stored in sy naptic granulae (3), is released upon electrical nerve stimulation (4 , 5) and acts at specific receptors (e .g. 6). Initially, much NPY-related work concerned its coexistence with classical transmitters (e. g . , norepinephrine) and its possible role in cotransmission; these lines of investigation coincided with the general acceptance that neurons use multiple messenger molecules, at least one of which is commonly a peptide. NPY has been frequently used to study cotransmission, particularly in its relation to the "classical" neurotransmitter norepinephrine , in mediating sympathetic vasoconstriction (6-9) . Although the role of NPY as a modulator of coreleased transmitter remains a focus for many investigators, it has been appreciated that NPY may also be an important messenger in its own right, perhaps particularly in the brain, where NP Y 0362-1 642/92/041 5-0309$02 .00 WAHLESTEDT potently induces, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Pharmacology and Toxicology Annual Reviews

Neuropeptide Y-Related Peptides and their Receptors--Are the Receptors Potential Therapeutic Drug Targets?

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References (72)

Publisher
Annual Reviews
Copyright
Copyright 1993 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0362-1642
eISSN
1545-4304
DOI
10.1146/annurev.pa.33.040193.001521
pmid
8494343
Publisher site
See Article on Publisher Site

Abstract

A decade has passed since the discovery of neuropeptide Y (also known as neuropeptide ty rosine or NPY) by Tatemoto &Mutt (1, 2). This 36-amino-acid peptide, arguably the most abundant and widely distributed of neuropeptides discovered to date, has stimulated several thousand scientific publications . NPY seems t o fulfill the main neurotransmitter criteria, since it i s stored in sy naptic granulae (3), is released upon electrical nerve stimulation (4 , 5) and acts at specific receptors (e .g. 6). Initially, much NPY-related work concerned its coexistence with classical transmitters (e. g . , norepinephrine) and its possible role in cotransmission; these lines of investigation coincided with the general acceptance that neurons use multiple messenger molecules, at least one of which is commonly a peptide. NPY has been frequently used to study cotransmission, particularly in its relation to the "classical" neurotransmitter norepinephrine , in mediating sympathetic vasoconstriction (6-9) . Although the role of NPY as a modulator of coreleased transmitter remains a focus for many investigators, it has been appreciated that NPY may also be an important messenger in its own right, perhaps particularly in the brain, where NP Y 0362-1 642/92/041 5-0309$02 .00 WAHLESTEDT potently induces,

Journal

Annual Review of Pharmacology and Toxicology – Annual Reviews

Published: Apr 1, 1993

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