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MULTIPROTEIN-DNA COMPLEXES IN TRANSCRIPTIONAL REGULATION

MULTIPROTEIN-DNA COMPLEXES IN TRANSCRIPTIONAL REGULATION ▪ Abstract Transcription in eukaryotes is frequently regulated by a mechanism termed combinatorial control, whereby several different proteins must bind DNA in concert to achieve appropriate regulation of the downstream gene. X-ray crystallographic studies of multiprotein complexes bound to DNA have been carried out to investigate the molecular determinants of complex assembly and DNA binding. This work has provided important insights into the specific protein-protein and protein-DNA interactions that govern the assembly of multiprotein regulatory complexes. The results of these studies are reviewed here, and the general insights into the mechanism of combinatorial gene regulation are discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Biophysics Annual Reviews

MULTIPROTEIN-DNA COMPLEXES IN TRANSCRIPTIONAL REGULATION

Annual Review of Biophysics , Volume 28 (1) – Jun 1, 1999

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References (114)

Publisher
Annual Reviews
Copyright
Copyright © 1999 by Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
1936-122X
eISSN
1936-1238
DOI
10.1146/annurev.biophys.28.1.29
pmid
10410794
Publisher site
See Article on Publisher Site

Abstract

▪ Abstract Transcription in eukaryotes is frequently regulated by a mechanism termed combinatorial control, whereby several different proteins must bind DNA in concert to achieve appropriate regulation of the downstream gene. X-ray crystallographic studies of multiprotein complexes bound to DNA have been carried out to investigate the molecular determinants of complex assembly and DNA binding. This work has provided important insights into the specific protein-protein and protein-DNA interactions that govern the assembly of multiprotein regulatory complexes. The results of these studies are reviewed here, and the general insights into the mechanism of combinatorial gene regulation are discussed.

Journal

Annual Review of BiophysicsAnnual Reviews

Published: Jun 1, 1999

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