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Metal Ion Sensors Based on DNAzymes and Related DNA Molecules

Metal Ion Sensors Based on DNAzymes and Related DNA Molecules Metal ion sensors are an important yet challenging field in analytical chemistry. Despite much effort, only a limited number of metal ion sensors are available for practical use because sensor design is often a trial-and-error-dependent process. DNAzyme-based sensors, in contrast, can be developed through a systematic selection that is generalizable for a wide range of metal ions. Here, we summarize recent progress in the design of DNAzyme-based fluorescent, colorimetric, and electrochemical sensors for metal ions, such as Pb 2+ , Cu 2+ , Hg 2+ , and UO 2 2+ . In addition, we also describe metal ion sensors based on related DNA molecules, including T-T or C-C mismatches and G-quadruplexes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Analytical Chemistry Annual Reviews
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