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Investigators have long sought to discover an exploitable metabolic lifference between the normal cell and the neoplastic cell. With this goal in nind, many compounds have been designed with exquisite biochemical easoning; however, when put through the acid test of a clinical trial, most of he effective agents have been incapable of discriminating to a significant legree between neoplastic and normal cells, especially those of the bone narrow and gastrointestinal tract. The current understanding of the :herapeutic effects of L-asparaginase represents the nearest approach to :uccess in this search. The development of L-asparaginase as a therapeutic agent began in _953 when Kidd (1, 2) reported that the growth of certain neoplasms in mice Lnd rats was inhibited by guinea pig serum but not by rabbit or horse sera. \t that time Kidd was investigating the possibility of immunotherapy for nurine lymphomas and was using guinea pig serum as a source of comple nent to enhance the antigen-antibody reaction with rabbit antilymphoma Lntisera. In the course of this work he observed that mice which received �uinea pig serum alone, experienced complete tumor regressions. At the :ime it was believed that an immunological phenomenon was operative iince the tumors were
Annual Review of Medicine – Annual Reviews
Published: Feb 1, 1970
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