Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
The past several years witnessed a general recognition by biologists that intracellular protein degradation is a fundamental process with important implications for bio chemical regulation, genetics, cell biology, physiology, and medicine. This realiza tion has led to a dramatic increase in the number of publications, reviews (1-7), and symposia (8-13) dealing with protein turnover and cell proteases. The present article focuses on recent progress in understanding the selectivity of protein degradation and its regulation under different physiological conditions. This article is a continuation of a review ("Intracellular Protein Degradation in Mammalian and Bacterial Cells") that appeared two years ago in the Annual Review of Biochemistry (1). The earlier publication discussed general features of protein degradation, methodology for measurement of degradative rates, the physiological significance of this process, and evidence that protein structure determined protein half-lives. The present review builds upon this background and focuses upon the recent findings in mammalian cells and in E. coli. This emphasis reflects both our own scientific interests and the fact that these systems have been studied most extensively. It has often been assumed that the mechanisms regulating protein levels in eukaryotic and prokaryotic organisms are profoundly different (3, 4). However, the degradative
Annual Review of Biochemistry – Annual Reviews
Published: Jul 1, 1976
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.