Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Intracellular Protein Degradation in Mammalian and Bacterial Cells: Part 2

Intracellular Protein Degradation in Mammalian and Bacterial Cells: Part 2 The past several years witnessed a general recognition by biologists that intracellular protein degradation is a fundamental process with important implications for bio­ chemical regulation, genetics, cell biology, physiology, and medicine. This realiza­ tion has led to a dramatic increase in the number of publications, reviews (1-7), and symposia (8-13) dealing with protein turnover and cell proteases. The present article focuses on recent progress in understanding the selectivity of protein degradation and its regulation under different physiological conditions. This article is a continuation of a review ("Intracellular Protein Degradation in Mammalian and Bacterial Cells") that appeared two years ago in the Annual Review of Biochemistry (1). The earlier publication discussed general features of protein degradation, methodology for measurement of degradative rates, the physiological significance of this process, and evidence that protein structure determined protein half-lives. The present review builds upon this background and focuses upon the recent findings in mammalian cells and in E. coli. This emphasis reflects both our own scientific interests and the fact that these systems have been studied most extensively. It has often been assumed that the mechanisms regulating protein levels in eukaryotic and prokaryotic organisms are profoundly different (3, 4). However, the degradative http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Biochemistry Annual Reviews

Intracellular Protein Degradation in Mammalian and Bacterial Cells: Part 2

Annual Review of Biochemistry , Volume 45 (1) – Jul 1, 1976

Loading next page...
 
/lp/annual-reviews/intracellular-protein-degradation-in-mammalian-and-bacterial-cells-Ap401BgH0k

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Annual Reviews
Copyright
Copyright 1976 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4154
eISSN
1545-4509
DOI
10.1146/annurev.bi.45.070176.003531
pmid
786161
Publisher site
See Article on Publisher Site

Abstract

The past several years witnessed a general recognition by biologists that intracellular protein degradation is a fundamental process with important implications for bio­ chemical regulation, genetics, cell biology, physiology, and medicine. This realiza­ tion has led to a dramatic increase in the number of publications, reviews (1-7), and symposia (8-13) dealing with protein turnover and cell proteases. The present article focuses on recent progress in understanding the selectivity of protein degradation and its regulation under different physiological conditions. This article is a continuation of a review ("Intracellular Protein Degradation in Mammalian and Bacterial Cells") that appeared two years ago in the Annual Review of Biochemistry (1). The earlier publication discussed general features of protein degradation, methodology for measurement of degradative rates, the physiological significance of this process, and evidence that protein structure determined protein half-lives. The present review builds upon this background and focuses upon the recent findings in mammalian cells and in E. coli. This emphasis reflects both our own scientific interests and the fact that these systems have been studied most extensively. It has often been assumed that the mechanisms regulating protein levels in eukaryotic and prokaryotic organisms are profoundly different (3, 4). However, the degradative

Journal

Annual Review of BiochemistryAnnual Reviews

Published: Jul 1, 1976

There are no references for this article.