Access the full text.
Sign up today, get DeepDyve free for 14 days.
M. Berg, D. Franken, G. Boers, H. Blom, C. Jakobs, C. Stehouwer, J. Rauwerda (1994)
Combined vitamin B6 plus folic acid therapy in young patients with arteriosclerosis and hyperhomocysteinemia.Journal of vascular surgery, 20 6
H. Refsum, S. Helland, P. Ueland (1985)
Radioenzymic determination of homocysteine in plasma and urine.Clinical chemistry, 31 4
Olov Wiklund, G. Bondjers, Irma Wright, G. Camejo (1996)
Insoluble complex formation between LDL and arterial proteoglycans in relation to serum lipid levels and effects of lipid lowering drugs.Atherosclerosis, 119 1
Thl (1991)
ORAL COBALAMIN FOR PERNICIOUS ANEMIA.NEJM Journal Watch, 1991
Soo-Sang Kang, Paul Wong, Jiemin Zhou, Judy Sora, Mira Lessick, Neal Ruggie, George Grcevich (1988)
Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease.Metabolism: clinical and experimental, 37 7
C. Dickinson (1995)
Does folic acid harm people with vitamin B12 deficiency?QJM : monthly journal of the Association of Physicians, 88 5
P. Verhoef, F. Kok, D. Kruyssen, E. Schouten, J. Witteman, D. Grobbee, P. Ueland, H. Refsum (1997)
Plasma total homocysteine, B vitamins, and risk of coronary atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology, 17 5
A. Eckardstein, M. Malinow, B. Upson, J. Heinrich, H. Schulte, Rainer Schonfeld, E. Kohler, G. Assmann (1994)
Effects of age, lipoproteins, and hemostatic parameters on the role of homocyst(e)inemia as a cardiovascular risk factor in men.Arteriosclerosis and thrombosis : a journal of vascular biology, 14 3
N. Pancharuniti, C. Lewis, H. Sauberlich, L. Perkins, R. Go, J. Alvarez, M. Macaluso, R. Acton, R. Copeland, A Cousins, T. Gore, P. Cornwell, J. Roseman (1994)
Plasma homocyst(e)ine, folate, and vitamin B-12 concentrations and risk for early-onset coronary artery disease.The American journal of clinical nutrition, 59 4
R. Rozen (1996)
Molecular genetics of methylenetetrahydrofolate reductase deficiency.Journal of inherited metabolic disease, 19 5
P. Frosst, H. Blom, R. Milos, P. Goyette, C. Sheppard, R. Matthews, G. Boers, M. Heijer, L. Kluijtmans, L. Heuve, R. Rozen (1995)
A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductaseNature Genetics, 10
J. Ubbink, W. Vermaak, A. Merwe, P. Becker (1993)
Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia.The American journal of clinical nutrition, 57 1
M. Spillmann, M. Fava (1996)
S-Adenosylmethionine (Ademetionine) in Psychiatric DisordersCNS Drugs, 6
T. Lancet, Nathaüe Put, R. Steegers-Theunissen, P. Frosst, F. Trijbels, T. Eskes, L. Heuvel, E. Mariman, Martin Heyer, R. Rozen, H. Blom (1995)
Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifidaThe Lancet, 346
Michael Tsai, M. Bignell, K. Schwichtenberg, N. Hanson (1996)
High prevalence of a mutation in the cystathionine beta-synthase gene.American journal of human genetics, 59 6
A. Bostom, D. Shemin, D. Shemin, D. Shemin, K. Lapane, K. Lapane, K. Lapane, A. Hume, A. Hume, A. Hume, D. Yoburn, D. Yoburn, D. Yoburn, M. Nadeau, M. Nadeau, M. Nadeau, A. Bendich, A. Bendich, A. Bendich, J. Selhub, J. Selhub, J. Selhub, I. Rosenberg, I. Rosenberg, I. Rosenberg (1996)
High dose-B-vitamin treatment of hyperhomocysteinemia in dialysis patients.Kidney international, 49 1
N. Put, T. Eskes, H. Blom (1997)
Is the common 677C-->T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis.QJM : monthly journal of the Association of Physicians, 90 2
A. Ness, J. Powles (1997)
Fruit and vegetables, and cardiovascular disease: a review.International journal of epidemiology, 26 1
N. Carson, D. Neill (1962)
Metabolic Abnormalities Detected in a Survey of Mentally Backward Individuals in Northern IrelandArchives of Disease in Childhood, 37
K. Rasmussen, J. Møller, M. Lyngbak, A. Pedersen, L. Dybkjaer (1996)
Age- and gender-specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation.Clinical chemistry, 42 4
Jonathan Silberberg, P. Finucane, R. Crooks, X. Guo, Jayne Fryer, J. Xie, John Wlodarczyk, N. Dudaman, B. Nair (1997)
Fasting and post-methionine homocyst(e)ine levels in a healthy Australian population.Australian and New Zealand journal of medicine, 27 1
M. Munshi, Angie Stone, L. Fink, V. Fonseca (1996)
Hyperhomocysteinemia following a methionine load in patients with non-insulin-dependent diabetes mellitus and macrovascular disease.Metabolism: clinical and experimental, 45 1
P. Harpel, Victor Chang, Wolfgang Borth (1992)
Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein(a) to fibrin: a potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism.Proceedings of the National Academy of Sciences of the United States of America, 89 21
A. Tawakol, T. Omland, M. Gerhard, James Wu, M. Creager (1997)
Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans.Circulation, 95 5
Patricia McAndrew, John Brandt, Dennis Pearl, Thomas Prior (1996)
The incidence of the gene for thermolabile methylene tetrahydrofolate reductase in African Americans.Thrombosis research, 83 2
M. Cattaneo, Maria Monzani, I. Martinelli, C. Falcon, P. Mannucci (1997)
Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism.Circulation, 97 3
E. Joosten, E. Lesaffre, R. Riezler, V. Ghekiere, L. Dereymaeker, W. Pelemans, E. Dejaeger (1997)
Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease?The journals of gerontology. Series A, Biological sciences and medical sciences, 52 2
P. Ueland, H. Refsum (2000)
Plasma Homocysteine and Cardiovascular Disease
M. Bots, M. Bots, L. Launer, J. Lindemans, A. Hofman, D. Grobbee, D. Grobbee (1997)
Homocysteine, atherosclerosis and prevalent cardiovascular disease in the elderly: The Rotterdam StudyJournal of Internal Medicine, 242
C. Agardh, E. Agardh, Arne Andersson, Björn Hultberg (1994)
Lack of association between plasma homocysteine levels and microangiopathy in type 1 diabetes mellitus.Scandinavian journal of clinical and laboratory investigation, 54 8
K. Storch, David Wagner, J. Burke, V. Young (1990)
[1-13C; methyl-2H3]methionine kinetics in humans: methionine conservation and cystine sparing.The American journal of physiology, 258 5 Pt 1
P. Ueland, Helga Refsum (1989)
Plasma homocysteine, a risk factor for vascular disease: plasma levels in health, disease, and drug therapy.The Journal of laboratory and clinical medicine, 114 5
Karen, Riggs, Katherine, Tucker, David, Rush (1996)
Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study.The American journal of clinical nutrition, 63 3
A. Lindgren, L. Brattström, B. Norrving, B. Hultberg, A. Andersson, B. Johansson (1995)
Plasma homocysteine in the acute and convalescent phases after stroke.Stroke, 26 5
P. Simioni, P. Prandoni, A. Burlina, D. Tormene, C. Sardella, V. Ferrari, L. Benedetti, A. Girolami (1996)
Hyperhomocysteinemia and deep-vein thrombosis. A case-control study.Thrombosis and haemostasis, 76 6
S. Tonstad, O. Joakimsen, E. Stensland-Bugge, T. Leren, L. Ose, D. Russell, K. Bønaa (1996)
Risk factors related to carotid intima-media thickness and plaque in children with familial hypercholesterolemia and control subjects.Arteriosclerosis, thrombosis, and vascular biology, 16 8
R. Steegers-Theunissen, G. Boers, H. Blom, F. Trijbels, T. Eskes (1992)
Hyperhomocysteinaemia and recurrent spontaneous abortion or abruptio placentaeThe Lancet, 339
J. Bachmann, Martin Tepel, H. Raidt, R. Riezler, U. Graefe, K. Langer, W. Zidek (1995)
Hyperhomocysteinemia and the risk for vascular disease in hemodialysis patients.Journal of the American Society of Nephrology : JASN, 6 1
O. Nygård, J. Nordrehaug, H. Refsum, P. Ueland, M. Farstad, S. Vollset (1997)
Plasma homocysteine levels and mortality in patients with coronary artery disease.The New England journal of medicine, 337 4
N. Dudman, C. Hicks, Jun Wang, D. Wilcken (1991)
Human arterial endothelial cell detachment in vitro: its promotion by homocysteine and cysteine.Atherosclerosis, 91 1-2
Milan Slavik, Kenneth Smith, Oscar Blanc (1982)
Decrease of serum pyridoxal phosphate levels and homocystinemia after administration of 6-azauridine triacetate and their prevention by administration of pyridoxine.Biochemical pharmacology, 31 24
P. Goyette, J. Sumner, R. Milos, A. Duncan, D. Rosenblatt, R. Matthews, R. Rozen (1994)
Human methylenetetrahydrofolate reductase: isolation of cDNA mapping and mutation identification.Nature genetics, 7 4
I. Currie, Y. Wilson, J. Scott, A. Day, D. Stansbie, R. Baird, P. Lamont, W. Tennant (1996)
Homocysteine: An independent risk factor for the failure of vascular interventionBritish Journal of Surgery, 83
(1991)
The prevalence of homocys - teinemia and hypercholesterolemia in angiographically defined coronary heart disease
Stephen Coburn (1996)
Modeling vitamin B6 metabolism.Advances in food and nutrition research, 40
J. Smythies, C. Gottfries, B. Regland (1997)
Disturbances of one-carbon metabolism in neuropsychiatric disorders: A reviewBiological Psychiatry, 41
G. Starkebaum, J. Harlan (1986)
Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine.The Journal of clinical investigation, 77 4
Soo-Sang Kang, Jeimin Zhou, P. Wong, J. Kowalisyn, G. Strokosch (1988)
Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase.American journal of human genetics, 43 4
L. Brattström, L. Tengborn, C. Lagerstedt, B. Israelsson, B. Hultberg (1991)
Plasma homocysteine in venous thromboembolism.Haemostasis, 21 1
C. Schmitz, K. Lindpaintner, P. Verhoef, J. Gaziano, Julie Buring (1996)
Genetic polymorphism of methylenetetrahydrofolate reductase and myocardial infarction. A case-control study.Circulation, 94 8
R. Wall, J. Harlan, L. Harker, G. Striker (1980)
Homocysteine-induced endothelial cell injury in vitro: a model for the study of vascular injury.Thrombosis research, 18 1-2
S. Kang, P. Wong, M. Malinow (1992)
Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease.Annual review of nutrition, 12
Geraldine Blundell, B. Jones, F. Rose, N. Tudball (1996)
Homocysteine mediated endothelial cell toxicity and its amelioration.Atherosclerosis, 122 2
Robillon Jf, B. Canivet, Mirande Candito, Sadoul Jl, D. Jullien, P. Morand, P. Chambon, P. Freychet (1994)
Type 1 diabetes mellitus and homocyst(e)ine.Diabete & metabolisme, 20 5
J. Miller, J. Ribaya-Mercado, R Russell, D Shepard, F Morrow, E. Cochary, J Sadowski, S. Gershoff, J. Selhub (1992)
Effect of vitamin B-6 deficiency on fasting plasma homocysteine concentrations.The American journal of clinical nutrition, 55 6
L. Brattström, B. Israelsson, F. Lindgärde, B. Hultberg (1988)
Higher total plasma homocysteine in vitamin B12 deficiency than in heterozygosity for homocystinuria due to cystathionine beta-synthase deficiency.Metabolism: clinical and experimental, 37 2
(1994)
The molecular genetics of homocystinuria , hyperhomocysteinemia , and premature vascular disease in Ireland
B. Dahlbäck (1995)
Inherited thrombophilia: resistance to activated protein C as a pathogenic factor of venous thromboembolism.Blood, 85 3
C. Glueck, Peter Shaw, J. Lang, T. Tracy, L. Sieve-Smith, Ying Wang (1995)
Evidence that homocysteine is an independent risk factor for atherosclerosis in hyperlipidemic patients.The American journal of cardiology, 75 2
(1992)
Lipid peroxidation in homocysteinemia
Lily Wu, James Wu, S. Hunt, B. James, G. Vincent, Roger Williams, P. Hopkins (1994)
Plasma homocyst(e)ine as a risk factor for early familial coronary artery disease.Clinical chemistry, 40 4
M. Mansoor, C. Bergmark, A. Svardal, P. Lønning, P. Ueland (1995)
Redox status and protein binding of plasma homocysteine and other aminothiols in patients with early-onset peripheral vascular disease. Homocysteine and peripheral vascular disease.Arteriosclerosis, thrombosis, and vascular biology, 15 2
L. Harker, J. Harlan, R. Ross (1983)
Effect of sulfinpyrazone on homocysteine-induced endothelial injury and arteriosclerosis in baboons.Circulation research, 53 6
M. Petri, R. Roubenoff, G. Dallal, M. Nadeau, J. Selhub, I. Rosenberg (1996)
Plasma homocysteine as a risk factor for atherothrombotic events in systemic lupus erythematosusThe Lancet, 348
W. Vermaak, J. Ubbink, H. Barnard, G. Potgieter, H. Jaarsveld, A Groenewald (1990)
Vitamin B-6 nutrition status and cigarette smoking.The American journal of clinical nutrition, 51 6
J. Ubbink, P. Becker, W. Vermaak, Rhena Delport (1995)
Results of B-vitamin supplementation study used in a prediction model to define a reference range for plasma homocysteine.Clinical chemistry, 41 7
Per, M., Ueland, Helga, Refsum, Sally, P. Stabler, Rene, Malinow (1993)
Total homocysteine in plasma or serum: methods and clinical applications.Clinical chemistry, 39 9
J. Ubbink, A. Merwe, Rhena Delport, R. Allen, S. Stabler, R. Riezler, W. Vermaak (1996)
The effect of a subnormal vitamin B-6 status on homocysteine metabolism.The Journal of clinical investigation, 98 1
M. Lucock, I. Daskalakis, J. Wild, Annie Anderson, C. Schorah, M. Lean, M. Levene (1996)
The influence of dietary folate and methionine on the metabolic disposition of endotoxic homocysteine.Biochemical and molecular medicine, 59 2
Y. Lolin, J. Sanderson, S. Cheng, C. Chan, C. Pang, K. Woo, J. Masarei (1996)
Hyperhomocysteinaemia and premature coronary artery disease in the Chinese.Heart, 76
J. Stamler, Adam Slivka (2009)
Biological chemistry of thiols in the vasculature and in vascular-related disease.Nutrition reviews, 54 1 Pt 1
A. Bostom, D. Shemin, P. Verhoef, M. Nadeau, P. Jacques, J. Selhub, L. Dworkin, I. Rosenberg (1997)
Elevated fasting total plasma homocysteine levels and cardiovascular disease outcomes in maintenance dialysis patients. A prospective study.Arteriosclerosis, thrombosis, and vascular biology, 17 11
I. Graham, Leslie Daly, H. Refsum, Killian Robinson, L. Brattström, P. Ueland, R. Palma-Reis, G. Boers, Richard Sheahan, Bo Israelsson, C. Uiterwaal, R. Meleady, Dorothy McMaster, Petra Verhoef, J. Witteman, P. Rubba, Hélène Bellet, Jan Wautrecht, Harold Valk, A. Luis, Francoise Parrot-Roulaud, Kok Tan, I. Higgins, Danielle Garcon, Maria Medrano, Mirande Candito, Alun Evans, Generoso Andria (1997)
Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project.JAMA, 277 22
R. Valentine, Harold Kaplan, Ralph Green, Donald Jacobsen, Stuart Myers, G. Clagett (1996)
Lipoprotein (a), homocysteine, and hypercoagulable states in young men with premature peripheral atherosclerosis: a prospective, controlled analysis.Journal of vascular surgery, 23 1
L. Brattström (1996)
Vitamins as homocysteine-lowering agents.The Journal of nutrition, 126 4 Suppl
E. Joosten, E. Lesaffre, R. Riezler (1996)
Are different reference intervals for methylmalonic acid and total homocysteine necessary in elderly people?European Journal of Haematology, 57
Katherine Tucker, Brenda Mahnken, P. Wilson, Paul Jacques, Jacob Selhub (1996)
Folic acid fortification of the food supply. Potential benefits and risks for the elderly population.JAMA, 276 23
A. Bostom, D. Shemin, M. Nadeau, V. Shih, S. Stabler, R. Allen, J. Selhub (1995)
Short term betaine therapy fails to lower elevated fasting total plasma homocysteine concentrations in hemodialysis patients maintained on chronic folic acid supplementation.Atherosclerosis, 113 1
D. Murphy-Chutorian, M. Wexman, A. Grieco, J. Heininger, E. Glassman, G. Gaull, Steven Ng, F. Feit, Karen Wexman, A. Fox (1985)
Methionine intolerance: a possible risk factor for coronary artery disease.Journal of the American College of Cardiology, 6 4
Tatsuya Hayashi, Gouichi Honda, Koji Suzuki (1992)
An atherogenic stimulus homocysteine inhibits cofactor activity of thrombomodulin and enhances thrombomodulin expression in human umbilical vein endothelial cells.Blood, 79 11
I. Fermo, C. Arcelloni, E. Vecchi, S. Viganó, R. Paroni (1992)
High-performance liquid chromatographic method with fluorescence detection for the determination of total homocyst(e)ine in plasma.Journal of chromatography, 593 1-2
(1981)
Effects of 2'-deoxycoformycin on homocysteine metabolism in acute lymphoblastic leukemia
Masanori Nishinaga, Toshio Ozawa, Kazuyuki Shimada (1993)
Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells.The Journal of clinical investigation, 92 3
Soo-Sang Kang, Soo-Sang Kang, P. Wong, P. Wong, Marija Norusis, Marija Norusis (1987)
Homocysteinemia due to folate deficiency.Metabolism: clinical and experimental, 36 5
T. Bienvenu, A. Ankri, B. Chadefaux, P. Kamoun (1991)
[Plasma homocysteine assay in the exploration of thrombosis in young subjects].Presse medicale, 20 21
Jing Ma, M. Stampfer, C. Hennekens, P. Frosst, J. Selhub, J. Horsford, M. Malinow, W. Willett, R. Rozen (1996)
Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians.Circulation, 94 10
C. Falcon, M. Cattaneo, Daniela Panzeri, I. Martinelli, P. Mannucci (1994)
High prevalence of hyperhomocyst(e)inemia in patients with juvenile venous thrombosis.Arteriosclerosis and thrombosis : a journal of vascular biology, 14 7
M. Malinow, P. Ducimetiere, G. Luc, A. Evans, D. Arveiler, F. Cambien, B. Upson (1996)
Plasma homocyst(e)ine levels and graded risk for myocardial infarction: findings in two populations at contrasting risk for coronary heart disease.Atherosclerosis, 126 1
A. Guttormsen, J. Schneede, T. Fiskerstrand, P. Ueland, H. Refsum (1994)
Plasma concentrations of homocysteine and other aminothiol compounds are related to food intake in healthy human subjects.The Journal of nutrition, 124 10
D. Wilcken, V. Gupta (1979)
Cysteine-homocysteine mixed disulphide: differing plasma concentrations in normal men and women.Clinical science, 57 2
Steven Lentz, J. Sadler (1991)
Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine.The Journal of clinical investigation, 88 6
A. Bostom, P. Jacques, M. Nadeau, Roger Williams, R. Ellison, J. Selhub (1995)
Post-methionine load hyperhomocysteinemia in persons with normal fasting total plasma homocysteine: initial results from the NHLBI Family Heart Study.Atherosclerosis, 116 1
Tore Amundsen, P. Ueland, A. Waage (1995)
Plasma homocysteine levels in patients with deep venous thrombosis.Arteriosclerosis, thrombosis, and vascular biology, 15 9
P. Hopkins, Lily Wu, James Wu, S. Hunt, B. James, G. Vincent, Roger Williams (1995)
Higher plasma homocyst(e)ine and increased susceptibility to adverse effects of low folate in early familial coronary artery disease.Arteriosclerosis, thrombosis, and vascular biology, 15 9
A. Araki, Y. Sako, Hideki Ito (1993)
Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment.Atherosclerosis, 103 2
P. Goyette, P. Frosst, D. Rosenblatt, R. Rozen (1995)
Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency.American journal of human genetics, 56 5
A. Bostom, R. Roubenoff, P. Dellaripa, M. Nadeau, P. Sutherland, P. Wilson, P. Jacques, J. Selhub, I. Rosenberg (1995)
Validation of abbreviated oral methionine-loading test.Clinical chemistry, 41 6 Pt 1
V. Kožich, E. Kraus, R. Franchis, B. Fowler, G. Boers, I. Graham, J. Kraus (1995)
Hyperhomocysteinemia in premature arterial disease: examination of cystathionine beta-synthase alleles at the molecular level.Human molecular genetics, 4 4
H. Refsum, F. Wesenberg, P. Ueland (1991)
Plasma homocysteine in children with acute lymphoblastic leukemia: changes during a chemotherapeutic regimen including methotrexate.Cancer research, 51 3
S. Rayne, F. Kraus (1993)
Placental thrombi and other vascular lesions. Classification, morphology, and clinical correlations.Pathology, research and practice, 189 1
S. Mudd (1989)
Disorders of transsulfuration, 1
O. Wiklund, G. Fager, A. Andersson, U. Lundstam, P. Masson, B. Hultberg (1996)
N-acetylcysteine treatment lowers plasma homocysteine but not serum lipoprotein(a) levels.Atherosclerosis, 119 1
A. Bostom, J. Brosnan, B. Hall, M. Nadeau, J. Selhub (1995)
Net uptake of plasma homocysteine by the rat kidney in vivo.Atherosclerosis, 116 1
B. Chadefaux, I. Ceballos, M. Hamet, M. Coudé, M. Poissonnier, P. Kamoun, D. Allard (1988)
IS ABSENCE OF ATHEROMA IN DOWN SYNDROME DUE TO DECREASED HOMOCYSTEINE LEVELS?The Lancet, 332
M. Shipchandler, E. Moore, Co, St. Louis, M. Malinow, H. Refsum, A. Andersson (1995)
Rapid, fully automated measurement of plasma homocyst(e)ine with the Abbott IMx analyzer.Clinical chemistry, 41 7
B. Herzlich, E. Lichstein, N. Schulhoff, Martin Weinstock, M. Pagala, K. Ravindran, T. Namba, F. Nieto, S. Stabler, R. Allen, M. Malinow (1996)
Relationship among homocyst(e)ine, vitamin B-12 and cardiac disease in the elderly: association between vitamin B-12 deficiency and decreased left ventricular ejection fraction.The Journal of nutrition, 126 4 Suppl
A. Guttormsen, A. Mansoor, T. Fiskerstrand, P. Ueland, H. Refsum (1993)
Kinetics of plasma homocysteine in healthy subjects after peroral homocysteine loading.Clinical chemistry, 39 7
E. Arnesen, H. Refsum, K. Bønaa, P. Ueland, O. Førde, J. Nordrehaug (1995)
Serum total homocysteine and coronary heart disease.International journal of epidemiology, 24 4
J. Ubbink, W. Vermaak, Annatjie Merwe, P. Becker (1992)
The effect of blood sample aging and food consumption on plasma total homocysteine levels.Clinica chimica acta; international journal of clinical chemistry, 207 1-2
C. Bower, Nicholas Wald (1995)
Vitamin B12 deficiency and the fortification of food with folic acid.European journal of clinical nutrition, 49 11
K. Robinson, E. Mayer, David Miller, R. Green, F. Lente, Anjan Gupta, K. Kottke-Marchant, S. Savon, J. Selhub, S. Nissen, M. Kutner, E. Topol, D. Jacobsen (1995)
Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease.Circulation, 92 10
A. Ermens, H. Refsum, J. Rupreht, L. Spijkers, A. Guttormsen, J. Lindemans, P. Ueland, J. Abels (1992)
Monitoring cobalamin inactivation during nitrous oxide anesthesia by determination of homocysteine and folate in plasma and urine.Clinical pharmacology and therapeutics, 49 4
L. Harker, R. Ross, S. Slichter, C. Scott (1976)
Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis.The Journal of clinical investigation, 58 3
Pierre Allain, A. Bouil, E. Cordillet, L. Quay, H. Bagheri, J. Montastruc (1995)
Sulfate and cysteine levels in the plasma of patients with Parkinson's disease.Neurotoxicology, 16 3
C. Boushey, S. Beresford, G. Omenn, A. Motulsky (1995)
A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes.JAMA, 274 13
K. Berg, M. Malinow, Pater Kiarulf, B. Upson (1992)
Population variation and genetics of plasma homocyst(e)ine levelClinical Genetics, 41
Serena Tonstad, H. Refsum, P. Ueland (1997)
Association between plasma total homocysteine and parental history of cardiovascular disease in children with familial hypercholesterolemia.Circulation, 96 6
P. Ueland (1995)
Homocysteine species as components of plasma redox thiol status.Clinical chemistry, 41 3
S. Tonstad, H. Refsum, L. Ose, P. Ueland (1998)
The C677T mutation in the methylenetetrahydrofolate reductase gene predisposes to hyperhomocysteinemia in children with familial hypercholesterolemia treated with cholestyramine.The Journal of pediatrics, 132 2
M. Malinow, S. Kang, L. Taylor, P. Wong, B. Coull, T. Inahara, D. Mukerjee, G. Sexton, B. Upson (1989)
Prevalence of hyperhomocyst(e)inemia in patients with peripheral arterial occlusive disease.Circulation, 79 6
M. Malinow, F. Nieto, M. Szklo, L. Chambless, G. Bond (1993)
Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The Atherosclerosis Risk in Communities Study.Circulation, 87 4
A. Andersson, L. Brattström, B. Israelsson, A. Isaksson, A. Hamfelt, B. Hultberg (1992)
Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal statusEuropean Journal of Clinical Investigation, 22
Finn Landgren, B. Israelsson, A. Lindgren, B. Hultberg, A. Andersson, L. Brattström (1995)
Plasma homocysteine in acute myocardial infarction: homocysteine‐lowering effect of folic acidJournal of Internal Medicine, 237
R. Clarke, L. Daly, K. Robinson, E. Naughten, S. Cahalane, B. Fowler, I. Graham (1991)
Hyperhomocysteinemia: an independent risk factor for vascular disease.The New England journal of medicine, 324 17
B. Israelsson, L. Brattström, B. Hultberg (1988)
Homocysteine and myocardial infarction.Atherosclerosis, 71 2-3
A. Guttormsen, J. Schneede, P. Ueland, H. Refsum (1996)
Kinetics of total plasma homocysteine in subjects with hyperhomocysteinemia due to folate or cobalamin deficiency.The American journal of clinical nutrition, 63 2
D. Harmon, J. Woodside, J. Yarnell, D. Mcmaster, I. Young, E. McCrum, K. Gey, A. Whitehead, A. Evans (1996)
The common 'thermolabile' variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia.QJM : monthly journal of the Association of Physicians, 89 8
M. Stampfer, E. Rimm (1996)
Folate and cardiovascular disease. Why we need a trial now.JAMA, 275
P. Jacques, A. Bostom, Roger Williams, R. Ellison, J. Eckfeldt, I. Rosenberg, J. Selhub, R. Rozen (1996)
Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations.Circulation, 93 1
M. Mansoor, P. Ueland, A. Aarsland, A. Svardal (1993)
Redox status and protein binding of plasma homocysteine and other aminothiols in patients with homocystinuria.Metabolism: clinical and experimental, 42 11
I. Perry, R. Morris, S. Ebrahim, A. Shaper, H. Refsum, P. Ueland (1995)
Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British menThe Lancet, 346
M. Sperandeo, R. Franchis, G. Andria, G. Sebastio (1996)
A 68-bp insertion found in a homocystinuric patient is a common variant and is skipped by alternative splicing of the cystathionine beta-synthase mRNA.American journal of human genetics, 59 6
L. Kluijtmans, L. Heuvel, G. Boers, P. Frosst, E. Stevens, B. Oost, M. Heijer, F. Trijbels, R. Rozen, H. Blom (1996)
Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.American journal of human genetics, 58 1
Atsushi Araki, Yoshiyasu Sako, Yutaka Fukushima, Mitsuhiro Matsumoto, Takeo Asada, Toru Kita (1989)
Plasma sulfhydryl-containing amino acids in patients with cerebral infarction and in hypertensive subjects.Atherosclerosis, 79 2-3
G. Alfthan, J. Pekkanen, M. Jauhiainen, J. Pitkäniemi, M. Karvonen, J. Tuomilehto, J. Salonen, C. Ehnholm (1994)
Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study.Atherosclerosis, 106 1
M. Tsai (1996)
Laboratory assessment of mild hyperhomocysteinemia as an independent risk factor for occlusive vascular diseases.Clinical chemistry, 42 4
S. Parthasarathy (1987)
Oxidation of low-density lipoprotein by thiol compounds leads to its recognition by the acetyl LDL receptor.Biochimica et biophysica acta, 917 2
R. Allen, S. Stabler, D. Savage, J. Lindenbaum (1993)
Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiencyThe FASEB Journal, 7
E. Uhlemann, J. TenPas, A. Lucky, J. Schulman, S. Mudd, N. Shulman (1976)
Platelet survival and morphology in homocystinuria due to cystathionine synthase deficiency.The New England journal of medicine, 295 23
S. Lentz, C. Sobey, D. Piegors, M. Bhopatkar, F. Faraci, M. Malinow, D. Heistad (1996)
Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia.The Journal of clinical investigation, 98 1
S. Tonstad, H. Refsum, M. Sivertsen, B. Christophersen, L. Ose, P. Ueland (1996)
Relation of Total Homocysteine and Lipid Levels in Children to Premature Cardiovascular Death in Male RelativesPediatric Research, 40
D. Franken, G. Boers, Henk Blom, J. Cruysberg, Frans Trijbels, Ben Hamel (1996)
Prevalence of familial mild hyperhomocysteinemia.Atherosclerosis, 125 1
L. Brattström, A. Lindgren, B. Israelsson, A. Andersson, B. Hultberg (1994)
Homocysteine and cysteine: determinants of plasma levels in middle‐aged and elderly subjectsJournal of Internal Medicine, 236
Theo Gerritsen, James Vaughn, H. Waisman (1962)
The identification of homocystine in the urine.Biochemical and biophysical research communications, 9
A. Guttormsen, P. Ueland, I. Nesthus, O. Nygård, J. Schneede, S. Vollset, H. Refsum (1996)
Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (> or = 40 micromol/liter). The Hordaland Homocysteine Study.The Journal of clinical investigation, 98 9
J. Marquet, B. Chadefaux, J. Bonnefont, J. Saudubray, J. Zittoun (1994)
Methylenetetrahydrofolate reductase deficiency: Prenatal diagnosis and family studiesPrenatal Diagnosis, 14
K. Robinson, Anjan Gupta, V. Dennis, K. Arheart, D. Chaudhary, R. Green, Paul Vigo, E. Mayer, J. Selhub, M. Kutner, D. Jacobsen (1996)
Hyperhomocysteinemia confers an independent increased risk of atherosclerosis in end-stage renal disease and is closely linked to plasma folate and pyridoxine concentrations.Circulation, 94 11
T. Deloughery, A. Evans, A. Sadeghi, J. McWilliams, W. Henner, L. Taylor, R. Press (1996)
Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine metabolism and late-onset vascular disease.Circulation, 94 12
G. Rodgers, Marion Conn (1990)
Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells.Blood, 75 4
S. Stabler, P. Marcell, E. Podell, R. Allen (1987)
Quantitation of total homocysteine, total cysteine, and methionine in normal serum and urine using capillary gas chromatography-mass spectrometry.Analytical biochemistry, 162 1
B. Christensen, A. Guttormsen, Jørm Schneede, B. Riedel, H. Refsum, A. Svardal, P. Ueland (1994)
Preoperative Methionine Loading Enhances Restoration of the Cobalamin‐dependent Enzyme Methionine Synthase after Nitrous Oxide AnesthesiaAnesthesiology, 80
N. Dudman, D. Wilcken, Jaw-Yuan Wang, James Lynch, D. Macey, P. Lundberg (1993)
Disordered methionine/homocysteine metabolism in premature vascular disease. Its occurrence, cofactor therapy, and enzymology.Arteriosclerosis and thrombosis : a journal of vascular biology, 13 9
S. Mudd, B. Uhlendorf, J. Freeman, J. Finkelstein, V. Shih (1972)
Homocystinuria associated with decreased methylenetetrahydrofolate reductase activity.Biochemical and biophysical research communications, 46 2
R. Franchis, F. Mancini, A. D’Angelo, G. Sebastio, I. Fermo, V. Stefano, M. Margaglione, G. Mazzola, G. Minno, G. Andria (1996)
Elevated total plasma homocysteine and 677C-->T mutation of the 5,10-methylenetetrahydrofolate reductase gene in thrombotic vascular disease.American journal of human genetics, 59 1
A. Bernstein (1990)
Vitamin B6 in Clinical NeurologyAnnals of the New York Academy of Sciences, 585
M. Heijer, T. Koster, Henk Blom, G. Bos, E. Briët, P. Reitsma, J. Vandenbroucke, F. Rosendaal (1996)
Hyperhomocysteinemia as a risk factor for deep-vein thrombosis.The New England journal of medicine, 334 12
C. Butterworth, T. Tamura (1989)
Folic acid safety and toxicity: a brief review.The American journal of clinical nutrition, 50 2
Marília Cravo, Lulsa Gloria, Jacob Seihub, Marie Nadeau (1996)
Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status.The American journal of clinical nutrition, 63 2
G. Alfthan, A. Aro, K. Gey (1997)
Plasma homocysteine and cardiovascular disease mortalityThe Lancet, 349
H. Blom, E. Molen (1994)
Pathobiochemical implications of hyperhomocysteinemiaFibrinolysis and Proteolysis, 8
C. Piyathilake, M. Macaluso, R. Hine, E. Richards, C. Krumdieck (1994)
Local and systemic effects of cigarette smoking on folate and vitamin B-12.The American journal of clinical nutrition, 60 4
L. Brattström, B. Israelsson, A. Olsson, Arne Andersson, B. Hultberg (1992)
Plasma homocysteine in women on oral oestrogen-containing contraceptives and in men with oestrogen-treated prostatic carcinoma.Scandinavian journal of clinical and laboratory investigation, 52 4
A. Subar, L. Harlan, M. Mattson (1990)
Food and nutrient intake differences between smokers and non-smokers in the US.American journal of public health, 80 11
M. Heijer, W. Gerrits, H. Haak, P. Wijermans, G. Bos, H. Blom, F. Rosendaal (1995)
Is hyperhomocysteinaemia a risk factor for recurrent venous thrombosis?The Lancet, 345
T. Goddijn-Wessel, Maurice Wouters, E. Molen, M. Spuijbroek, R. Steegers-Theunissen, Henk Blom, G. Boers, T. Eskes (1996)
Hyperhomocysteinemia: a risk factor for placental abruption or infarction.European journal of obstetrics, gynecology, and reproductive biology, 66 1
M. Stampfer, M. Malinow, W. Willett, L. Newcomer, B. Upson, D. Ullmann, P. Tishler, C. Hennekens (1992)
A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians.JAMA, 268 7
Z. Tazi, Patrice Cacoub, Fabien Koskas, A. Chabanel, B. Chadefaux-Vekemans, M. Horellou, Viard Jp, J. Piette, Edouard Kieffer, P. Godeau (1996)
[Value of an extensive biological study in venous or arterial thromboses].Presse medicale, 25 11
K. Hajjar (1993)
Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor.The Journal of clinical investigation, 91 6
D. Dastur, E. Quadros, N. Wadia, M. Desai, E. Bharucha (1972)
Effect of Vegetarianism and Smoking on Vitamin B12, Thiocyanate, and Folate Levels in the Blood of Normal SubjectsBritish Medical Journal, 3
W. Castelli (1996)
Lipids, risk factors and ischaemic heart disease.Atherosclerosis, 124 Suppl
(1997)
Human methionine synthase cDNA cloning, gene localization and expression
K. Mccully, K. Mccully, R. Wilson, R. Wilson (1975)
Homocysteine theory of arteriosclerosis.Atherosclerosis, 22 2
P. Verhoef, Hennekens Ch, Malinow Mr, F. Kok, W. Willett, M. Stampfer (1994)
A Prospective Study of Plasma Homocyst(e)ine and Risk of Ischemic StrokeStroke, 25
Astrid Engbersen, D. Franken, G. Boers, E. Stevens, F. Trijbels, H. Blom (1995)
Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia.American journal of human genetics, 56 1
Jia Chen, E. Giovannucci, K. Kelsey, E. Rimm, M. Stampfer, G. Colditz, D. Spiegelman, W. Willett, D. Hunter (1996)
A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer.Cancer research, 56 21
D. Wilcken, Xing-Li Wang, A. Sim, R. Mccredie (1996)
Distribution in healthy and coronary populations of the methylenetetrahydrofolate reductase (MTHFR) C677T mutation.Arteriosclerosis, thrombosis, and vascular biology, 16 7
L. Brattstrom, J. Hardebo, B. Hultberg (1984)
Moderate Homocysteinemia - A Possible Risk Factor For Arteriosclerotic Cerebrovascular DiseaseStroke, 15
R. Jacob, Mei-Miau Wu, Susanne Henning, M. Swendseid (1994)
Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl group restriction.The Journal of nutrition, 124 7
I. Fermo, S. D'angelo, R. Paroni, G. Mazzola, G. Calori, A. D’Angelo (1995)
Prevalence of Moderate Hyperhomocysteinemia in Patients with Early-Onset Venous and Arterial Occlusive DiseaseAnnals of Internal Medicine, 123
G. Boers, A. Smals, F. Trijbels, B. Fowler, J. Bakkeren, H. Schoonderwaldt, W. Kleijer, P. Kloppenborg (1985)
Heterozygosity for homocystinuria in premature peripheral and cerebral occlusive arterial disease.The New England journal of medicine, 313 12
J. Kraus, Kim Le, M. Swaroop, Toshihiro Ohura, Takahiro Tahara, Leon Rosenberg, Michael Roper, Viktor Kožlch (1993)
Human cystathionine beta-synthase cDNA: sequence, alternative splicing and expression in cultured cells.Human molecular genetics, 2 10
S. Mudd, '. Havlik, H. Levy, V. McKusick, M. Feinleib (1981)
A study of cardiovascular risk in heterozygotes for homocystinuria.American journal of human genetics, 33 6
R. Allen, S. Stabler, J. Lindenbaum (1993)
Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism.Metabolism: clinical and experimental, 42 11
D. Rosenblatt, B. Cooper (1990)
Inherited disorders of vitamin B12 utilizationBioEssays, 12
J. Graeber, J. Slott, R. Ulane, J. Schulman, M. Stuart (1982)
Effect of Homocysteine and Homocystine on Platelet and Vascular Arachidonic Acid MetabolismPediatric Research, 16
I. Graham, R. Meleady (1996)
Heart attacks and homocysteineBMJ, 313
L. Brattström, B. Israelsson, B. Norrving, D. Bergqvist, J. Thörne, B. Hultberg, A. Hamfelt (1990)
Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease. Effects of pyridoxine and folic acid treatment.Atherosclerosis, 81 1
Soo-Sang Kang, Paul Wong, Anil Bidani, Sylvia Milanez (1983)
Plasma protein-bound homocyst(e)ine in patients requiring chronic haemodialysis.Clinical science, 65 3
Richard Armstrong (1995)
Beta-amyloid deposition in the medial temporal lobe in elderly non-demented brains and in Alzheimer's disease.Dementia, 6 3
J. Lindenbaum, I. Rosenberg, P. Wilson, S. Stabler, R. Allen (1994)
Prevalence of cobalamin deficiency in the Framingham elderly population.The American journal of clinical nutrition, 60 1
B. Christensen, P. Frosst, S. Lussier‐Cacan, J. Selhub, P. Goyette, D. Rosenblatt, J. Genest, R. Rozen (1997)
Correlation of a common mutation in the methylenetetrahydrofolate reductase gene with plasma homocysteine in patients with premature coronary artery disease.Arteriosclerosis, thrombosis, and vascular biology, 17 3
A. Guttormsen, P. Ueland, E. Svarstad, H. Refsum (1997)
Kinetic basis of hyperhomocysteinemia in patients with chronic renal failure.Kidney international, 52 2
J. Gibson, N. Carson, D. Neill (1964)
Pathological findings in homocystinuriaJournal of Clinical Pathology, 17
S. Vollset, O. Nygård, G. Kvåle, P. Ueland, H. Refsum (1997)
The Hordaland Homocysteine Study: Lifestyle and Total Plasma Homocysteine in Western Norway
A. Mager (2000)
Methylenetetrahydrofolate reductase gene and coronary artery disease.Circulation, 101 16
D. Wilcken, B. Wilcken (1976)
The pathogenesis of coronary artery disease. A possible role for methionine metabolism.The Journal of clinical investigation, 57 4
T. Garrow (1996)
Purification, Kinetic Properties, and cDNA Cloning of Mammalian Betaine-Homocysteine Methyltransferase*The Journal of Biological Chemistry, 271
G. Bos, M. Heijer (1998)
Hyperhomocysteinemia and Venous ThrombosisSeminars in Thrombosis and Hemostasis, 24
H. Refsum, S. Helland, P. Ueland (1989)
Fasting plasma homocysteine as a sensitive parameter of antifolate effect: A study of psoriasis patients receiving low‐dose methotrexate treatmentClinical Pharmacology & Therapeutics, 46
L. Brattström, B. Israelsson, J. Jeppsson, B. Hultberg (1988)
Folic acid--an innocuous means to reduce plasma homocysteine.Scandinavian journal of clinical and laboratory investigation, 48 3
G. Anker, P. Lønning, P. Ueland, H. Refsum, E. Lien (2006)
Plasma levels of the atherogenic amino acid homocysteine in postmenopausal women with breast cancer treated with tamoxifenInternational Journal of Cancer, 60
T. Bienvenu, A. Ankri, B. Chadefaux, G. Montalescot, P. Kamoun (1993)
Elevated total plasma homocysteine, a risk factor for thrombosis. Relation to coagulation and fibrinolytic parameters.Thrombosis research, 70 2
J. Ellis, K. Mccully (1995)
Prevention of myocardial infarction by vitamin B6.Research communications in molecular pathology and pharmacology, 89 2
F. Stammler, C. Diehm, E. Hsu, Kurt Stockinger, K. Amendt (2008)
Prävalenz der Hyperhomocysteinämie bei der Thrombangiitis obliterans: Spielt Homocystein pathogenetisch eine Rolle?DMW, 121
R. Steegers-Theunissen, G. Boers, Frans Trijbels, James Finkelstein, Henk Blom, Christopher Thomas, George Borm, Maurice Wouters, T. Eskes (1994)
Maternal hyperhomocysteinemia: a risk factor for neural-tube defects?Metabolism: clinical and experimental, 43 12
P. Rubba, M. Mercuri, F. Faccenda, A. Iannuzzi, C. Irace, P. Strisciuglio, A. Gnasso, R. Tang, G. Andria, M. Bond, M. Mancini (1994)
Premature Carotid Atherosclerosis: Does It Occur in Both Familial Hypercholesterolemia and Homocystinuria? Ultrasound Assessment of Arterial Intima‐Media Thickness and Blood Flow VelocityStroke, 25
B. Halvorsen, I. Brude, C. Drevon, Jette Nysom, L. Ose, E. Christiansen, Marit Nenseterl (1996)
Effect of homocysteine on copper ion-catalyzed, azo compound-initiated, and mononuclear cell-mediated oxidative modification of low density lipoprotein.Journal of lipid research, 37 7
H. Refsum, P. Ueland (1990)
Clinical significance of pharmacological modulation of homocysteine metabolism.Trends in pharmacological sciences, 11 10
N. Dudman, D. Wilcken, R. Stocker (1993)
Circulating lipid hydroperoxide levels in human hyperhomocysteinemia. Relevance to development of arteriosclerosis.Arteriosclerosis and thrombosis : a journal of vascular biology, 13 4
K. Mccully (1969)
Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.The American journal of pathology, 56 1
(1997)
Influence of thyroid dysfunction on the plasma level of the atherogenic amino acid homocysteine. Metabolism
Soo-Sang Kang, P. Wong, P. Glickman, C. MacLeod, I. Jaffe (1986)
Protein‐Bound Homocyst(e)ine in Patients With Rheumatoid Arthritis Undergoing D‐Penicillamine TreatmentThe Journal of Clinical Pharmacology, 26
S. Lussier‐Cacan, Marianne Xhignesse, Alain Piolot, Jacob Selhub, Jean Davignon, J. Genest (1996)
Plasma total homocysteine in healthy subjects: sex-specific relation with biological traits.The American journal of clinical nutrition, 64 4
Michael Tsai, Uttam Garg, Nigel Key, Naomi Hanson, A. Suh, K. Schwichtenberg (1996)
Molecular and biochemical approaches in the identification of heterozygotes for homocystinuria.Atherosclerosis, 122 1
J. Tsai, Hong Wang, M. Perrella, M. Yoshizumi, N. Sibinga, L. Tan, E. Haber, T. Chang, R. Schlegel, Mu-En Lee (1996)
Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells.The Journal of clinical investigation, 97 1
M. Berg, C. Stehouwer, E. Bierdrager, J. Rauwerda (1996)
Plasma homocysteine and severity of atherosclerosis in young patients with lower-limb atherosclerotic disease.Arteriosclerosis, thrombosis, and vascular biology, 16 1
S. Mudd, J. Poole (1975)
Labile methyl balances for normal humans on various dietary regimens.Metabolism: clinical and experimental, 24 6
M. Adams, P. Smith, D. Martin, J. Thompson, D. Lodwick, N. Samani (1996)
Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction.QJM : monthly journal of the Association of Physicians, 89 6
J. Møller, K. Rasmussen (1995)
Homocysteine in plasma: stabilization of blood samples with fluoride.Clinical chemistry, 41 5
H. Valk, M. Eeden, J. Banga, R. Griend, E. Groot, F. Haas, O. Meuwissen, M. Durán, J. Smeitink, B. Poll‐The, J. Klerk, D. Wittebol-Post, M. Rolland (1996)
Evaluation of the presence of premature atherosclerosis in adults with heterozygosity for cystathionine-beta-synthase deficiency.Stroke, 27 6
L. Kluijtmans, John Kastelein, J. Lindemans, G. Boers, Sandra Heil, A. Bruschke, J. Jukema, Lambert Heuvel, Frans Trijbels, Geert Boerma, F. Verheugt, Frank Willems, Henk Blom (1997)
Thermolabile methylenetetrahydrofolate reductase in coronary artery disease.Circulation, 96 8
J. Selhub, P. Jacques, A. Bostom, R. D’Agostino, P. Wilson, A. Belanger, D. O'leary, P. Wolf, E. Schaefer, I. Rosenberg (1995)
Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis.The New England journal of medicine, 332 5
O. Nygård, S. Vollset, H. Refsum, I. Stensvold, A. Tverdal, J. Nordrehaug, P. Ueland, G. Kvåle (1995)
Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study.JAMA, 274 19
J. Schneede, P Dagnelie, W. Staveren, S. Vollset, H. Refsum, P. Ueland (1994)
Methylmalonic Acid and Homocysteine in Plasma as Indicators of Functional Cobalamin Deficiency in Infants on Macrobiotic DietsPediatric Research, 36
G. Boers, A. Smals, F. Trijbels, A. Leermakers, P. Kloppenborg (1983)
Unique efficiency of methionine metabolism in premenopausal women may protect against vascular disease in the reproductive years.The Journal of clinical investigation, 72 6
J. Stamler, J. Osborne, Omar Jaraki, L. Rabbani, M. Mullins, D. Singel, J. Loscalzo (1993)
Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen.The Journal of clinical investigation, 91 1
Soo-Sang Kang, W. Paul, K., Wong, Heron Cook, Marija Norusis, Joseph, V., Messer (1986)
Protein-bound homocyst(e)ine. A possible risk factor for coronary artery disease.The Journal of clinical investigation, 77 5
O. Nygård, H. Refsum, P. Ueland, S. Vollset (1998)
Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study.The American journal of clinical nutrition, 67 2
P. Verhoef, C. Hennekens, R. Allen, S. Stabler, W. Willett, M. Stampfer (1997)
Plasma total homocysteine and risk of angina pectoris with subsequent coronary artery bypass surgery.The American journal of cardiology, 79 6
Carolyn O'Keefe, L. Bailey, Elizabeth Thomas, Sarah Hofler, Barbara Davis, James Cerda, J. Gregory (1995)
Controlled dietary folate affects folate status in nonpregnant women.The Journal of nutrition, 125 10
Jones Sl, G. Viberti (1995)
Renal functional reserve in subjects with diabetes mellitus.Seminars in nephrology, 15 5
J. Selhub, P. Jacques, P. Wilson, D. Rush, I. Rosenberg (1993)
Vitamin status and intake as primary determinants of homocysteinemia in an elderly population.JAMA, 270 22
D. Blankenhorn, M. Malinow, W. Mack (1991)
Colestipol plus niacin therapy elevates plasma homocyst(e)ine levelsCoronary Artery Disease, 2
A. Bostom, Lori Lathrop (1997)
Hyperhomocysteinemia in end-stage renal disease: prevalence, etiology, and potential relationship to arteriosclerotic outcomes.Kidney international, 52 1
Paula Gallagher, R. Meleady, D. Shields, K. Tan, D. Mcmaster, R. Rozen, A. Evans, Ian Graham, A. Whitehead (1996)
Homocysteine and risk of premature coronary heart disease. Evidence for a common gene mutation.Circulation, 94 9
Steven Lentz, J. Sadler (1993)
Homocysteine inhibits von Willebrand factor processing and secretion by preventing transport from the endoplasmic reticulum.Blood, 81 3
A. Motulsky (1996)
Nutritional ecogenetics: homocysteine-related arteriosclerotic vascular disease, neural tube defects, and folic acid.American journal of human genetics, 58 1
G. Hankey, J. Eikelboom (1999)
Homocysteine and vascular diseaseThe Lancet, 354
D. Leclerc, E. Campeau, P. Goyette, C. Adjalla, B. Christensen, M. Ross, P. Eydoux, D. Rosenblatt, R. Rozen, R. Gravel (1996)
Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders.Human molecular genetics, 5 12
M. Wouters, M. Moorrees, M. Mooren, H. Blom, G. Boers, L. Schellekens, Christopher Thomas, T. Eskes (1995)
Plasma homocysteine and menopausal status **European Journal of Clinical Investigation, 25
G. Rodgers, W. Kane (1986)
Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator.The Journal of clinical investigation, 77 6
T. Fiskerstrand, H. Refsum, G. Kvalheim, P. Ueland (1993)
Homocysteine and other thiols in plasma and urine: automated determination and sample stability.Clinical chemistry, 39 2
J. Finkelstein (1990)
Methionine metabolism in mammals.The Journal of nutritional biochemistry, 1 5
A. Levin (1997)
Folate and heart disease: theoretical link needs study.Annals of internal medicine, 126 4
B. Fowler, I. Sardharwalla, A. Robins (1971)
The detection of heterozygotes for homocystinuria by oral loading with L-methionine.The Biochemical journal, 122 1
Yunan Li, S. Gulati, Priscilla Baker, L. Brody, R. Banerjee, W. Kruger (1996)
Cloning, mapping and RNA analysis of the human methionine synthase gene.Human molecular genetics, 5 12
D. Wilcken, V. Gupta (1979)
Sulphur containing amino acids in chronic renal failure with particular reference to homocystine and cysteine‐homocysteine mixed disulphideEuropean Journal of Clinical Investigation, 9
P. Verhoef, M. Stampfer, M. Stampfer, Julie Buring, J. Gaziano, R. Allen, S. Stabler, R. Reynolds, F. Kok, C. Hennekens, C. Hennekens, W. Willett, W. Willett (1996)
Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate.American journal of epidemiology, 143 9
K. Dalery, K. Dalery, S. Lussier‐Cacan, S. Lussier‐Cacan, J. Selhub, J. Selhub, J. Davignon, J. Davignon, Y. Latour, Y. Latour, J. Genest, J. Genest (1995)
Homocysteine and coronary artery disease in French Canadian subjects: relation with vitamins B12, B6, pyridoxal phosphate, and folate.The American journal of cardiology, 75 16
M. Malinow, J. Levenson, Philippe Giral, F. Nieto, M. Razavian, P. Segond, Alain Simon (1995)
Role of blood pressure, uric acid, and hemorheological parameters on plasma homocyst(e)ine concentration.Atherosclerosis, 114 2
J. Haworth, L. Dilling, R. Surtees, L. Seargeant, H. Lue-Shing, B. Cooper, D. Rosenblatt (1993)
Symptomatic and asymptomatic methylenetetrahydrofolate reductase deficiency in two adult brothers.American journal of medical genetics, 45 5
(1989)
Fasting plasma homocysteine as a sensitive parameter to antifolate effect
B. Lubec, O. Labudová, H. Hoeger, A. Muehl, S. Fang-Kircher, M. Marx, W. Mosgoeller, J. Gialamas (1996)
Homocysteine increases cyclin-dependent kinase in aortic rat tissue.Circulation, 94 10
J. Lindenbaum, E. Healton, David Savage, J. Brust, T. Garrett, E. Podell, P. Marcell, S. Stabler, R. Allen (1988)
Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis.The New England journal of medicine, 318 26
G. Sebastio, M. Sperandeo, Michele Panico, R. Franchis, Jan Kraus, '. GenerosoAndria (1995)
The molecular basis of homocystinuria due to cystathionine beta-synthase deficiency in Italian families, and report of four novel mutations.American journal of human genetics, 56 6
M. Mooren, Maurice Wouters, Henk Blom, L. Schellekens, T. Eskes, Rune Rolland (1994)
Hormone replacement therapy may reduce high serum homocysteine in postmenopausal womenEuropean Journal of Clinical Investigation, 24
R. Schimke, V. McKusick, T. Huang, A. Pollack (1965)
HOMOCYSTINURIA. STUDIES OF 20 FAMILIES WITH 38 AFFECTED MEMBERS.JAMA, 193
Franziska Loehrer, Christian Angst, W. Haefeli, Paul Jordan, R. Ritz, Brian Fowler (1996)
Low whole-blood S-adenosylmethionine and correlation between 5-methyltetrahydrofolate and homocysteine in coronary artery disease.Arteriosclerosis, thrombosis, and vascular biology, 16 6
J. Heinecke, H. Rosen, L. Suzuki, A. Chait (1987)
The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells.The Journal of biological chemistry, 262 21
D. Brenton, D. Cusworth, C. Dent, E. Jones (1966)
Homocystinuria. Clinical and dietary studies.The Quarterly journal of medicine, 35 139
M. Árnadóttir, B. Hultberg, P. Nilsson‐Ehle, H. Thysell (1996)
The effect of reduced glomerular filtration rate on plasma total homocysteine concentration.Scandinavian journal of clinical and laboratory investigation, 56 1
O. Nygård, H. Refsum, P. Ueland, I. Stensvold, J. Nordrehaug, G. Kvåle, S. Vollset (1997)
Coffee consumption and plasma total homocysteine: The Hordaland Homocysteine Study.The American journal of clinical nutrition, 65 1
I. Quéré, H. Lamarti, B. Chadefaux-Vekemans (1996)
Thrombophilia, homocystinuria, and mutation of the factor V gene.The New England journal of medicine, 335 4
F. Lederle (1991)
Oral cobalamin for pernicious anemia. Medicine's best kept secret?JAMA, 265 1
H. Mandel, B. Brenner, Moshe Berant, N. Rosenberg, N. Lanir, C. Jakobs, B. Fowler, U. Seligsohn (1996)
Coexistence of hereditary homocystinuria and factor V Leiden--effect on thrombosis.The New England journal of medicine, 334 12
A. Hill (1965)
The Environment and Disease: Association or Causation?Journal of the Royal Society of Medicine, 58
J. Ubbink, W. Vermaak, A. Merwe, P. Becker, Rhena Delport, H. Potgieter (1994)
Vitamin requirements for the treatment of hyperhomocysteinemia in humans.The Journal of nutrition, 124 10
S. Mudd, J. Finkelstein, F. Irreverre, L. Laster (1964)
Homocystinuria: An Enzymatic DefectScience, 143
▪ Abstract An elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial and venous thromboembolism. The basis for these conclusions is data from about 80 clinical and epidemiological studies including more than 10,000 patients. Elevated tHcy confers a graded risk with no threshold, is independent of but may enhance the effect of the conventional risk factors, and seems to be a particularly strong predictor of cardiovascular mortality. Hyperhomocysteinemia is attributed to commonly occurring genetic and acquired factors including deficiencies of folate and vitamin B12. Supplementation with B-vitamins, in particular with folic acid, is an efficient, safe, and inexpensive means to reduce an elevated tHcy level. Studies are now in progress to establish whether such therapy will reduce cardiovascular risk.
Annual Review of Medicine – Annual Reviews
Published: Feb 1, 1998
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.