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Control of Gene Expression

Control of Gene Expression This review is divided into the fourteen stations of the operon model: the structure of repressor; the function of repressor; the binding of RNA polymerase to DNA; the initiation, propagation, and regulation of RNA synthesis; the degradation of RNA; the nature and location of promoter regions; the function and location of operator regions; the initiation and termination of translation of polycistronic mRNA and the phenomenon o f polarity. Sections are also included on DNA-RNA h ybridizat ion and the role of t RN A in reg u l ation . REPRESSOR Chemical nature of the repressor.-Jacob & Monod (1) postulated that operons are under negative control: that for each operon there is a regula­ tory gene which speci fie s the structure of a repressor; that a repressor is a 1 The following abbreviations and definitions are used: The term in vitro is taken to mean cell-free extracts. Coordinate induction or repression is used to indicate a constant ratio of enzyme specific activities at all levels of induction or repression as originalI y defined (170). In this sense, even enzymes of an operon which increase in a fixed ratio upon induction but whose basal levels do not exhibit http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Genetics Annual Reviews

Control of Gene Expression

Martin, R G
Annual Review of Genetics , Volume 3 (1) – Dec 1, 1969
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Publisher
Annual Reviews
Copyright
Copyright 1969 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4197
eISSN
1545-2948
DOI
10.1146/annurev.ge.03.120169.001145
Publisher site
See Article on Publisher Site

Abstract

This review is divided into the fourteen stations of the operon model: the structure of repressor; the function of repressor; the binding of RNA polymerase to DNA; the initiation, propagation, and regulation of RNA synthesis; the degradation of RNA; the nature and location of promoter regions; the function and location of operator regions; the initiation and termination of translation of polycistronic mRNA and the phenomenon o f polarity. Sections are also included on DNA-RNA h ybridizat ion and the role of t RN A in reg u l ation . REPRESSOR Chemical nature of the repressor.-Jacob & Monod (1) postulated that operons are under negative control: that for each operon there is a regula­ tory gene which speci fie s the structure of a repressor; that a repressor is a 1 The following abbreviations and definitions are used: The term in vitro is taken to mean cell-free extracts. Coordinate induction or repression is used to indicate a constant ratio of enzyme specific activities at all levels of induction or repression as originalI y defined (170). In this sense, even enzymes of an operon which increase in a fixed ratio upon induction but whose basal levels do not exhibit

Journal

Annual Review of Genetics – Annual Reviews

Published: Dec 1, 1969

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