Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/annual-reviews/chromosomal-abnormalities-in-human-neoplasia-fwjzLWSvcW
References
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
- Publisher
- Annual Reviews
- Copyright
- Copyright 1970 Annual Reviews. All rights reserved
- Subject
- Review Articles
- ISSN
- 0066-4219
- eISSN
- 1545-326X
- DOI
- 10.1146/annurev.me.21.020170.002115
- pmid
- 4247449
- Publisher site
- See Article on Publisher Site
Abstract
The salient aims of this review will be to evaluate chromosomal changes in human neoplasia as they bear on three important areas: 1. the specificity of such changes ; 2. the information gleaned from karyotypic variations which may throw light upon the more fundamental processes and under standing of human neoplasia, and 3. the clinical applicability of chromosomal findings. To accomplish this task we have attempted to utilize th e pertinent data published in the literature and have included for reference those articles which have cogent and relatively complete clinical, histologic, and cyto genetic data for the purposes of this review. No attempt has been made to include all published papers, for not only do limitations of space preclude such an approach, but often articles contain too scanty clinical or cytologic information to be reliably interpreted for the aims of this review. The chromosomal changes in human neoplastic disorders appear to be confined to the tissue involved, with all other somatic cells being diploid. Congenitally determined karyotypic abnormalities, coincidentally occurring in an occasional patient with neoplasia, may appear in consortium with the chromosomal changes caused by the cancer. In cancer of any origin the cytogenetic abnormalities are found
Journal
Annual Review of Medicine – Annual Reviews
Published: Feb 1, 1970