Introduction to session I, part B, section 2
Abstract
PhDâ I, part B, section Evidence accumulated over more than 40 The work of Dr Ip and his colleagues supyr has clearly established that rats and mice ports our conclusions (2) that both the type fed high-fat diets ad libitum develop tumors and amount of dietary fat can influence the of mammary tumors induced by of the mammary gland, colon, and pancreas yields more readily than do those fed low-fat diets. DMBA. Thus far, however, it has not been These results have attracted interest because possible to demonstrate any relationship bemortality from cancers at these sites is posi- tween breast cancer mortality in human popand the degree of polyunsaturation tively correlated with dietary fat in human ulations fatty acids, possibly because most populations. High-fat diets have a higher ca-of dietary diets contain sufficient linoleic acid to loric density than low-fat diets and caloric in-human satisfy the requirement for essential fatty acids. take is positively correlated with dietary fat The positive correlation between breast cancer (1). It is therefore pertinent to consider the and dietary fat in human popularelative importance of caloric intake and spe- mortality tions may therefore be related primarily to the cific components of dietary fat