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The Journal of Nutrition , Volume 33 (1): 53 – Jan 1, 1947


American Society for Nutrition
Copyright © by the American Society for Nutrition
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It has long been recognized that the animal body is capable accumulating vitamin A that the liver is the chief storage site (Osborne Mendel, '18). Studies regarding the distribution stored vitamin A in the rat 's body have shown that 90 to 95% is found in the liver (Sherman Boynton, '25; Moore, '31; McCoord Luce-Clausen, '34) that the liver content the vitamin is usually proportional to the intake (Baumann, Riising Steenbock, '34). The liver stores the vitamin may indicate both the state nutrition the animal the availability the vitamin when admin istered under different conditions. In the following pages an investigation the influence the sex the animal, the le^el intake, the source the vitamin the mode administration on the storage vitamin A in the liver the rat is reported. PROCEDURE Weanling rats from our breeding colony were maintained in air conditioned quarters (75°F., 0% relative humidity) on 4 the U.S.P. vitamin A-free diet composed the following in gredients: purified casein, 18%; acetone-washed cornstarch, 65% ; salt mixture, 4% (Jones Foster, '42) ; acetone washed brewer's yeast, 8%; cottonseed oil, 5%; vitamin D, 6 units per gm ration. When their weights remained sta tionary or declined for a period
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