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of folate and B - vitamin deficiency), riboflavin, flavin mononucleotide (reflecting riboflavin status), pyridoxal 5 -phosphate ( vitamin B6), 3-hydroxykynurenine (HK), kynurenic acid (KA), anthranilic acid (AA ...
and plasma . Biomarker . Matrixa . Kinetics . Error level, % b . k/k1, h−1 . k2 (h−1) . g . tb (h) . DT50 (h) . Model . B vitamins and related nutrients Folate ( 5 -methyltetrahydrofolate) S 0.0028**c >192 SFO ...
associated with some pathological conditions and cancers (1). Patients with breast (4), colon ( 5 , 6 ), bladder (7), or laryngeal (8) cancers and or Hodgkin’s disease (1) have lower plasma PLP levels compared ...
. Heparinized blood samples were collected from the vein before (0 h) and at 6 h, 6 days and 15 days after administration. Three forms of vitamin B6 (pyridoxin, pyridoxal and pyridoxamine) were measured in plasma ...
of cardiovascular disease, fetal malformations, dementia, and neuropsychiatric symptoms among patients on AEDs ( 5 )( 6 )(7). Homocysteine metabolism is dependent on four B vitamins as cofactors: The methylation ...
, Wagner C. Vitamin B6 deficiency in uremia. Am J Clin Nutr 1975; 28: 950–957 Google Scholar 13 Spannuth C, Warnock L, Wagner C, Stone W. Increased plasma clearance of pyridoxal 5 '‐phosphate in vitamin B6 ...
) or by functional assays such as prothrombin time ( 5 ). The direct quantification of phylloquinone concentration in plasma is the best indicator of vitamin K status and has been associated with dietary intake (15)(16 ...
modification, the HPLC analysis time being extended from 6 to 10 min. The plasma and RBC free AA concentrations were determined by HPLC, as previously described [9]. Concentrations of pyridoxal ‐ 5 ′‐phosphate (PLP ...
, pyridoxal 5 -phosphate (PLP), was markedly decreased at 2% of reference median concentration (Table 1). Table 1. Plasma concentrations of vitamins and metabolites in the transsulfuration and kynurenine ...
) Pyridoxine ( vitamin B6)/ pyridoxal 5 ′-phosphate Aldehyde group oxidation C/E Gerdes et al. (2012) Aldehyde group condensations C Dalling et al. (1976) Dephosphorylation E Gerdes et al. (2012) 6 -Hydroxylation C ...
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