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Journals Journal of Virology Volume 86 Issue 4

The Andes Hantavirus NSs Protein Is Expressed from the Viral Small mRNA by a Leaky Scanning Mechanism Jorge Vera-Otarola a , Loretto Solis a , Ricardo Soto-Rifo b , Emiliano P. Ricci b , Karla Pino a , Nicole D. Tischler c , Théophile Ohlmann b , Jean-Luc Darlix d and Marcelo López-Lastra a a Laboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Centro de Investigaciones Médicas, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile b TEV, Unité de Virologie Humaine INSERM 758, IFR 128, ENS de Lyon, Lyon, France c Fundación Ciencia y Vida, Santiago, Chile d LaboRetro, Unité de Virologie Humaine INSERM 758, IFR 128, ENS de Lyon, Lyon, France ABSTRACT The small mRNA (SmRNA) of all Bunyaviridae encodes the nucleocapsid (N) protein. In 4 out of 5 genera in the Bunyaviridae , the smRNA encodes an additional nonstructural protein denominated NSs. In this study, we show that Andes hantavirus (ANDV) SmRNA encodes an NSs protein. Data show that the NSs protein is expressed in the context of an ANDV infection. Additionally, our results suggest that translation initiation from the NSs initiation codon is mediated by ribosomal subunits that have bypassed the upstream N protein initiation codon through a leaky scanning mechanism.

The Andes Hantavirus NSs Protein Is Expressed from the Viral Small mRNA by a Leaky Scanning Mechanism

Abstract

The Andes Hantavirus NSs Protein Is Expressed from the Viral Small mRNA by a Leaky Scanning Mechanism Jorge Vera-Otarola a , Loretto Solis a , Ricardo Soto-Rifo b , Emiliano P. Ricci b , Karla Pino a , Nicole D. Tischler c , Théophile Ohlmann b , Jean-Luc Darlix d and Marcelo López-Lastra a a Laboratorio de Virología Molecular, Instituto Milenio de Inmunología e Inmunoterapia, Centro de Investigaciones Médicas, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile b TEV, Unité de Virologie Humaine INSERM 758, IFR 128, ENS de Lyon, Lyon, France c Fundación Ciencia y Vida, Santiago, Chile d LaboRetro, Unité de Virologie Humaine INSERM 758, IFR 128, ENS de Lyon, Lyon, France ABSTRACT The small mRNA (SmRNA) of all Bunyaviridae encodes the nucleocapsid (N) protein. In 4 out of 5 genera in the Bunyaviridae , the smRNA encodes an additional nonstructural protein denominated NSs. In this study, we show that Andes hantavirus (ANDV) SmRNA encodes an NSs protein. Data show that the NSs protein is expressed in the context of an ANDV infection. Additionally, our results suggest that translation initiation from the NSs initiation codon is mediated by ribosomal subunits that have bypassed the upstream N protein initiation codon through a leaky scanning mechanism.

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The Andes Hantavirus NSs Protein Is Expressed from the Viral Small mRNA by a Leaky Scanning Mechanism

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  • Publisher American Society for Microbiology
  • Copyright Copyright © 2012 by the American society for Microbiology.
  • ISSN 0022-538X
  • eISSN 1098-5514
  • D.O.I. 10.1128/JVI.06223-11
  • Publisher site Get PDF  

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