Structure of adenylylated streptomycin synthesized enzymatically by Bacillus subtilis.
AbstractReceive: RSS Feeds, eTOCs, free email alerts (when new articles cite this article), moreÂ» Information about commercial reprint orders: http://aac.asm.org/site/misc/reprints.xhtml To subscribe to to another ASM Journal go to: http://journals.asm.org/site/subscriptions/ Letters to the Editor Antacids and Ciprofloxacin Pharmacokinetics We wish to congratulate Dr. Golper and collaborators on the excellent research on ciprofloxacin in continuous ambulatory peritoneal dialysis (1). Nevertheless, the authors neither reported the antacid dosage and the dosing interval nor indicated whether the antacid intake was concomitant or delayed with respect to ciprofloxacin administration. This information could have been interesting, since the interaction between quinolones and antacids to form chelated complexes has been well documented (H. C. Neu, Quinolone Bull. 2:1, 1985; P. M. Sah, Quinolone Bull. 2:12, 1986); in addition, some controversial data concerning the extent of this interaction have been published (2, 3). In fact, the influence on quinolone kinetics exerted by antacids seems to depend especially on their dosage and dosing schedule. For this reason, a 2-h interval between the concomitant administration of cation-containing antacids in therapeutic doses and quinolones has been advised (4). LITERATURE CITED 1. Golper, T. A., A. I. Hartstein, V. H. Morthland, and J. M. Christensen. 1987. Effects of antacids