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Journals Clinical and Vaccine Immunology Volume 19 Issue 2

Serum Hemagglutination Inhibition Activity Correlates with Protection from Gastroenteritis in Persons Infected with Norwalk Virus Rita Czakó a , b , Robert L. Atmar a , b , c , Antone R. Opekun c , d , Mark A. Gilger d , David Y. Graham b , c and Mary K. Estes a , b , c a Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas b Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas c Department of Medicine, Baylor College of Medicine, Houston, Texas d Department of Pediatrics, Baylor College of Medicine, Houston, Texas ABSTRACT A hemagglutination inhibition (HAI) assay to assess serum antibody responses following Norwalk virus (NV) infection was developed. HAI activity increased significantly in individuals experimentally infected with NV ( n = 18) and correlated with antibody levels measured in a histo-blood group antigen (HBGA) blocking assay. Prechallenge HAI antibody levels also correlated with protection from the development of gastroenteritis (Mann-Whitney test, P = 0.02). The HAI assay is another assay suitable for the detection of antibody that correlates with protection from Norwalk virus-associated disease.

Serum Hemagglutination Inhibition Activity Correlates with Protection from Gastroenteritis in Persons Infected with Norwalk Virus

Abstract

Serum Hemagglutination Inhibition Activity Correlates with Protection from Gastroenteritis in Persons Infected with Norwalk Virus Rita Czakó a , b , Robert L. Atmar a , b , c , Antone R. Opekun c , d , Mark A. Gilger d , David Y. Graham b , c and Mary K. Estes a , b , c a Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas b Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas c Department of Medicine, Baylor College of Medicine, Houston, Texas d Department of Pediatrics, Baylor College of Medicine, Houston, Texas ABSTRACT A hemagglutination inhibition (HAI) assay to assess serum antibody responses following Norwalk virus (NV) infection was developed. HAI activity increased significantly in individuals experimentally infected with NV ( n = 18) and correlated with antibody levels measured in a histo-blood group antigen (HBGA) blocking assay. Prechallenge HAI antibody levels also correlated with protection from the development of gastroenteritis (Mann-Whitney test, P = 0.02). The HAI assay is another assay suitable for the detection of antibody that correlates with protection from Norwalk virus-associated disease.

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Serum Hemagglutination Inhibition Activity Correlates with Protection from Gastroenteritis in Persons Infected with Norwalk Virus

Czakó, Rita; Atmar, Robert L.; Opekun, Antone R.; Gilger, Mark A.; Graham, David Y.; Estes, Mary K.
Clinical and Vaccine Immunology , Volume 19 (2): 284
American Society For Microbiology – Feb 1, 2012

More Info
  • Publisher American Society for Microbiology
  • Copyright Copyright © 2012 by the American society for Microbiology.
  • ISSN 1556-6811
  • eISSN 1556-679X
  • D.O.I. 10.1128/CVI.05592-11
  • Publisher site Get PDF  

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