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Rcs and PhoPQ Regulatory Overlap in the Control of Salmonella enterica Virulence

Rcs and PhoPQ Regulatory Overlap in the Control of Salmonella enterica Virulence Rcs and PhoPQ Regulatory Overlap in the Control of Salmonella enterica Virulence ▿ Clara B. García-Calderón , Josep Casadesús , and Francisco Ramos-Morales * Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Apartado 1095, 41080 Sevilla, Spain ABSTRACT Genetic screens based on the use of Mu d J-generated lac fusions permitted the identification of novel genes regulated by the Rcs signal transduction system in Salmonella enterica serovar Typhimurium. Besides genes that are also found in the Escherichia coli genome, our screens identified Salmonella -specific genes regulated by RcsB, including bapA , siiE , srfA , and srfB . Here we show that the srfABC operon is negatively regulated by RcsB and by PhoP. In vivo studies using mutants with constitutive activation of the Rcs and/or PhoPQ system suggested that there is an overlap between these regulatory systems in the control of Salmonella virulence. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Bacteriology American Society For Microbiology

Rcs and PhoPQ Regulatory Overlap in the Control of Salmonella enterica Virulence

Rcs and PhoPQ Regulatory Overlap in the Control of Salmonella enterica Virulence

Journal of Bacteriology , Volume 189 (18): 6635 – Sep 15, 2007

Abstract

Rcs and PhoPQ Regulatory Overlap in the Control of Salmonella enterica Virulence ▿ Clara B. García-Calderón , Josep Casadesús , and Francisco Ramos-Morales * Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Apartado 1095, 41080 Sevilla, Spain ABSTRACT Genetic screens based on the use of Mu d J-generated lac fusions permitted the identification of novel genes regulated by the Rcs signal transduction system in Salmonella enterica serovar Typhimurium. Besides genes that are also found in the Escherichia coli genome, our screens identified Salmonella -specific genes regulated by RcsB, including bapA , siiE , srfA , and srfB . Here we show that the srfABC operon is negatively regulated by RcsB and by PhoP. In vivo studies using mutants with constitutive activation of the Rcs and/or PhoPQ system suggested that there is an overlap between these regulatory systems in the control of Salmonella virulence.

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Publisher
American Society For Microbiology
Copyright
Copyright © 2007 by the American society for Microbiology.
ISSN
0021-9193
eISSN
1098-5530
DOI
10.1128/JB.00640-07
pmid
17616593
Publisher site
See Article on Publisher Site

Abstract

Rcs and PhoPQ Regulatory Overlap in the Control of Salmonella enterica Virulence ▿ Clara B. García-Calderón , Josep Casadesús , and Francisco Ramos-Morales * Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Apartado 1095, 41080 Sevilla, Spain ABSTRACT Genetic screens based on the use of Mu d J-generated lac fusions permitted the identification of novel genes regulated by the Rcs signal transduction system in Salmonella enterica serovar Typhimurium. Besides genes that are also found in the Escherichia coli genome, our screens identified Salmonella -specific genes regulated by RcsB, including bapA , siiE , srfA , and srfB . Here we show that the srfABC operon is negatively regulated by RcsB and by PhoP. In vivo studies using mutants with constitutive activation of the Rcs and/or PhoPQ system suggested that there is an overlap between these regulatory systems in the control of Salmonella virulence.

Journal

Journal of BacteriologyAmerican Society For Microbiology

Published: Sep 15, 2007

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