Population Pharmacokinetic Analysis of Ceftobiprole for Treatment of Complicated Skin and Skin Structure Infections
Abstract
Population Pharmacokinetic Analysis of Ceftobiprole for Treatment of Complicated Skin and Skin Structure Infections ▿ Holly Kimko * , Bindu Murthy , Xu Xu , Partha Nandy , Richard Strauss and Gary J. Noel Johnson & Johnson Pharmaceutical Research & Development LLC, Raritan, NJ ABSTRACT Population pharmacokinetic analysis demonstrated that renal function, as assessed by creatinine clearance (CL CR ), was the patient characteristic that had a clinically relevant impact on ceftobiprole pharmacodynamics. Dosing adjustments based on CL CR for subjects with renal impairment should provide ceftobiprole exposure similar to that in patients with normal renal function.