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Population Pharmacokinetic Analysis of Ceftobiprole for Treatment of Complicated Skin and Skin Structure Infections

Antimicrobial Agents and Chemotherapy , Volume 53 (3): 1228 – Mar 1, 2009

Details

Publisher
American Society for Microbiology
Copyright
Copyright © 2009 by the American society for Microbiology.
ISSN
0066-4804
eISSN
1098-6596
D.O.I.
10.1128/AAC.00632-08
Publisher site
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Population Pharmacokinetic Analysis of Ceftobiprole for Treatment of Complicated Skin and Skin Structure Infections

Abstract

Population Pharmacokinetic Analysis of Ceftobiprole for Treatment of Complicated Skin and Skin Structure Infections ▿ Holly Kimko * , Bindu Murthy , Xu Xu , Partha Nandy , Richard Strauss and Gary J. Noel Johnson & Johnson Pharmaceutical Research & Development LLC, Raritan, NJ ABSTRACT Population pharmacokinetic analysis demonstrated that renal function, as assessed by creatinine clearance (CL CR ), was the patient characteristic that had a clinically relevant impact on ceftobiprole pharmacodynamics. Dosing adjustments based on CL CR for subjects with renal impairment should provide ceftobiprole exposure similar to that in patients with normal renal function.
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