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Population Pharmacokinetic Analysis of Ceftobiprole for Treatment of Complicated Skin and Skin Structure Infections

Population Pharmacokinetic Analysis of Ceftobiprole for Treatment of Complicated Skin and Skin Structure Infections Population Pharmacokinetic Analysis of Ceftobiprole for Treatment of Complicated Skin and Skin Structure Infections ▿ Holly Kimko * , Bindu Murthy , Xu Xu , Partha Nandy , Richard Strauss and Gary J. Noel Johnson & Johnson Pharmaceutical Research & Development LLC, Raritan, NJ ABSTRACT Population pharmacokinetic analysis demonstrated that renal function, as assessed by creatinine clearance (CL CR ), was the patient characteristic that had a clinically relevant impact on ceftobiprole pharmacodynamics. Dosing adjustments based on CL CR for subjects with renal impairment should provide ceftobiprole exposure similar to that in patients with normal renal function. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Antimicrobial Agents and Chemotherapy American Society For Microbiology

Population Pharmacokinetic Analysis of Ceftobiprole for Treatment of Complicated Skin and Skin Structure Infections

Abstract

Population Pharmacokinetic Analysis of Ceftobiprole for Treatment of Complicated Skin and Skin Structure Infections ▿ Holly Kimko * , Bindu Murthy , Xu Xu , Partha Nandy , Richard Strauss and Gary J. Noel Johnson & Johnson Pharmaceutical Research & Development LLC, Raritan, NJ ABSTRACT Population pharmacokinetic analysis demonstrated that renal function, as assessed by creatinine clearance (CL CR ), was the patient characteristic that had a clinically relevant impact on ceftobiprole pharmacodynamics. Dosing adjustments based on CL CR for subjects with renal impairment should provide ceftobiprole exposure similar to that in patients with normal renal function.
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