Subscribe to thousands of academic journals for just $40/month
Read and share the articles you need for your research, all in one place.

Optimal Meropenem Concentrations To Treat Multidrug-Resistant Pseudomonas aeruginosa Septic Shock

Antimicrobial Agents and Chemotherapy , Volume 56 (4): 2129 – Apr 1, 2012

Details

Publisher
American Society for Microbiology
Copyright
Copyright © 2012 by the American society for Microbiology.
ISSN
0066-4804
eISSN
1098-6596
D.O.I.
10.1128/AAC.06389-11
Publisher site
See Article on Publisher Site

Preview Only

Expand Tray Hide Tray

Optimal Meropenem Concentrations To Treat Multidrug-Resistant Pseudomonas aeruginosa Septic Shock

Abstract

Optimal Meropenem Concentrations To Treat Multidrug-Resistant Pseudomonas aeruginosa Septic Shock Fabio Silvio Taccone a , Frédéric Cotton b , Sandrine Roisin c , Jean-Louis Vincent a and Frédérique Jacobs d a Department of Intensive Care, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium b Department of Clinical Biology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium c Department of Microbiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium d Department of Infectious Diseases, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium ABSTRACT A patient with septic shock due to extensively drug resistant (XDR) Pseudomonas aeruginosa was cured by optimizing the meropenem (MEM) regimen to obtain at least 40% of the time between two administrations in which drug levels were four times higher than the MIC of the pathogen. As the standard drug dose did not achieve these optimal concentrations, the MEM regimen was progressively increased up to 12 g/day (3 g every 6 h in a 3-h extended infusion), which eventually resulted in sepsis resolution. High MEM dosage may represent a valuable therapeutic option for infection due to multidrug-resistant (MDR) strains, and drug monitoring would allow rapid regimen adjustment in clinical practice.
Loading next page...

Preview Only. This article cannot be rented because we do not currently have permission from the publisher.

 
/lp/american-society-for-microbiology/optimal-meropenem-concentrations-to-treat-multidrug-resistant-j4Y9eBI9t2