Mutational synergism between heat and sublethal dosages of ultraviolet light in Escherichia coli strains.
Abstract
Receive: RSS Feeds, eTOCs, free email alerts (when new articles cite this article), more» Information about commercial reprint orders: http://jb.asm.org/site/misc/reprints.xhtml To subscribe to to another ASM Journal go to: http://journals.asm.org/site/subscriptions/ JOURNAL OF BACTERIOLOGY, Apr. 1968, p. 1486-1488 Copyright @ 1968 American Society for Microbiology Vol. 95, No. 4 Printed in U.S.A ARIS S. SIDEROPOULOS,' ROBERT C. JOHNSON, AND DELBERT M. SHANKEL Department of Microbiology, Un?iversity of Kansas, Lawrence, Kansas 66044 Received for publication 26 January 1968 It has been previously observed that heating at lethal and sublethal temperatures produces an increase in the spontaneous rate of mutations in Escherichia coli. The heating of E. coli strains W6 and 15 at 55 to 60 C (below the melting temperature of deoxyribonucleic acid) increased the spontaneous rate of mutation (S. Zamenhof and S. B. Greer, Nature 182:611, 1958). Heat also apparently caused some depurination of deoxyribonucleic acid (S. B. Greer and S. Zamenhof, J. Mol. Biol. 4:123, 1962), and hence must also induce chain breakage. Temperature effects on the production of mutations have also been found in Tradescantia (K. Sax, Genetics 22:523, 1937), Drosophila (H. H. Plough, Cold Spring Harbor Symp. Quant. Biol. 9:127, 1941), and Neurospora (B. J. Kilbey,