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Molecular Characterization of Newly Emerged bla KPC-2 -Producing Klebsiella pneumoniae in Singapore Michelle N. D. Balm , Grace Ngan , Roland Jureen , Raymond T. P. Lin and Jeanette Teo Department of Laboratory Medicine, National University Hospital, Singapore ABSTRACT In Asia, bla KPC detection has been limited to East Asia and not yet seen in Southeast Asia. We report four bla KPC-2 -containing Klebsiella pneumoniae isolates from two different hospitals in Singapore. All isolates belonged to strain type 11 (ST11) and were indistinguishable by pulsed-field gel electrophoresis (PFGE). bla KPC-2 was located on nonconjugative plasmids and flanked by mobile genetic structures composed of a partial Tn 4401 transposon and a Tn 3 -based transposon which previously have been described only in Chinese isolates.

Molecular Characterization of Newly Emerged blaKPC-2-Producing Klebsiella pneumoniae in Singapore

Abstract

Molecular Characterization of Newly Emerged bla KPC-2 -Producing Klebsiella pneumoniae in Singapore Michelle N. D. Balm , Grace Ngan , Roland Jureen , Raymond T. P. Lin and Jeanette Teo Department of Laboratory Medicine, National University Hospital, Singapore ABSTRACT In Asia, bla KPC detection has been limited to East Asia and not yet seen in Southeast Asia. We report four bla KPC-2 -containing Klebsiella pneumoniae isolates from two different hospitals in Singapore. All isolates belonged to strain type 11 (ST11) and were indistinguishable by pulsed-field gel electrophoresis (PFGE). bla KPC-2 was located on nonconjugative plasmids and flanked by mobile genetic structures composed of a partial Tn 4401 transposon and a Tn 3 -based transposon which previously have been described only in Chinese isolates.

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Molecular Characterization of Newly Emerged blaKPC-2-Producing Klebsiella pneumoniae in Singapore

Balm, Michelle N. D.; Ngan, Grace; Jureen, Roland; Lin, Raymond T. P.; Teo, Jeanette
Journal of Clinical Microbiology , Volume 50 (2): 475
American Society For MicrobiologyFeb 1, 2012

More Info

  • Publisher American Society for Microbiology
  • Copyright Copyright © 2012 by the American society for Microbiology.
  • ISSN 0095-1137
  • eISSN 1098-660X
  • D.O.I. 10.1128/JCM.05914-11
  • Publisher site Get PDF  

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