Microbiological Aspects of Penicillin : II. Turbidimetric Studies on Penicillin Inhibition
Abstract
CONTENT ALERTS Receive: RSS Feeds, eTOCs, free email alerts (when new articles cite this article), more» Information about commercial reprint orders: http://jb.asm.org/site/misc/reprints.xhtml To subscribe to to another ASM Journal go to: http://journals.asm.org/site/subscriptions/ II. TuRBIDIMETRIC STUDIES ON PENICILLIN INhIBITION JACKSON W. FOSTER AND BERNARD L. WILKER Research Laboratory, Merck & Co., Inc., Rahway, N. J. Received for publication May 19, 1943 The character of bacterial growth-inhibition as a function of penicillin concentration when influenced by imposed conditions may have a bearing on the nature of penicillin action. Turbidimetry has proved of some value in this respect. Indeed, this method appears to be the only feasible manner of analyzing certain effects. A satisfactory method for the quantitative estimation of penicillin based on the proportional inhibition of bacterial growth measured turbidimetrically has already been described (Foster, 1942), and a discussion of certain of its features has appeared in the preceding paper of this series (Foster and Woodruff, 1943). The main portion of this paper deals with various applications of turbidimetry to the study of in vitro penicillin effects. Supplementary data pertaining to the procedure itself and certain other findings are also presented. EXPERIMENTAL Downloaded from http://jb.asm.org/ on December 9, 2011 by