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Importance of Infusion Volume and Pump Characteristics in Extended Administration of β-Lactam Antibiotics

Importance of Infusion Volume and Pump Characteristics in Extended Administration of β-Lactam... Importance of Infusion Volume and Pump Characteristics in Extended Administration of β-Lactam Antibiotics ▿ Barbara Claus * , Franky Buyle and Hugo Robays Pharmacy Department Dirk Vogelaers Department of Internal Medicine and Infectious Diseases Ghent University Hospital De Pintelaan 185, Ghent 9000, Belgium The introduction of a new protocol at Ghent University Hospital (Ghent, Belgium) for the extended administration of piperacillin-tazobactam (TZP) and meropenem drew attention to a potential pitfall that is well-known in daily clinical practice but often neglected, i.e., the contribution of infusion line dead space to the incomplete administration of the drug. The Antibiotic Policy Working Party at the institution implemented an extended 3-h protocol for TZP and meropenem administration in both intensive care units (ICU) and regular wards. The protocol specified that TZP is to be infused as a loading dose of 4.5 g over 30 min, followed by a 3-h infusion of 4.5 g every 6 h, with dosage adjustments according to renal function. For meropenem, a 1-g loading dose over 30 min is to be followed by a 3-h infusion of 1 g every 8 h. Dose regimens are based upon the Belgian version of the Sanford guide ( 5 ). Extended http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Antimicrobial Agents and Chemotherapy American Society For Microbiology

Importance of Infusion Volume and Pump Characteristics in Extended Administration of β-Lactam Antibiotics

Importance of Infusion Volume and Pump Characteristics in Extended Administration of β-Lactam Antibiotics

Antimicrobial Agents and Chemotherapy , Volume 54 (11): 4950 – Nov 1, 2010

Abstract

Importance of Infusion Volume and Pump Characteristics in Extended Administration of β-Lactam Antibiotics ▿ Barbara Claus * , Franky Buyle and Hugo Robays Pharmacy Department Dirk Vogelaers Department of Internal Medicine and Infectious Diseases Ghent University Hospital De Pintelaan 185, Ghent 9000, Belgium The introduction of a new protocol at Ghent University Hospital (Ghent, Belgium) for the extended administration of piperacillin-tazobactam (TZP) and meropenem drew attention to a potential pitfall that is well-known in daily clinical practice but often neglected, i.e., the contribution of infusion line dead space to the incomplete administration of the drug. The Antibiotic Policy Working Party at the institution implemented an extended 3-h protocol for TZP and meropenem administration in both intensive care units (ICU) and regular wards. The protocol specified that TZP is to be infused as a loading dose of 4.5 g over 30 min, followed by a 3-h infusion of 4.5 g every 6 h, with dosage adjustments according to renal function. For meropenem, a 1-g loading dose over 30 min is to be followed by a 3-h infusion of 1 g every 8 h. Dose regimens are based upon the Belgian version of the Sanford guide ( 5 ). Extended

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References (8)

Publisher
American Society For Microbiology
Copyright
Copyright © 2010 by the American society for Microbiology.
ISSN
0066-4804
eISSN
1098-6596
DOI
10.1128/AAC.00754-10
pmid
20823285
Publisher site
See Article on Publisher Site

Abstract

Importance of Infusion Volume and Pump Characteristics in Extended Administration of β-Lactam Antibiotics ▿ Barbara Claus * , Franky Buyle and Hugo Robays Pharmacy Department Dirk Vogelaers Department of Internal Medicine and Infectious Diseases Ghent University Hospital De Pintelaan 185, Ghent 9000, Belgium The introduction of a new protocol at Ghent University Hospital (Ghent, Belgium) for the extended administration of piperacillin-tazobactam (TZP) and meropenem drew attention to a potential pitfall that is well-known in daily clinical practice but often neglected, i.e., the contribution of infusion line dead space to the incomplete administration of the drug. The Antibiotic Policy Working Party at the institution implemented an extended 3-h protocol for TZP and meropenem administration in both intensive care units (ICU) and regular wards. The protocol specified that TZP is to be infused as a loading dose of 4.5 g over 30 min, followed by a 3-h infusion of 4.5 g every 6 h, with dosage adjustments according to renal function. For meropenem, a 1-g loading dose over 30 min is to be followed by a 3-h infusion of 1 g every 8 h. Dose regimens are based upon the Belgian version of the Sanford guide ( 5 ). Extended

Journal

Antimicrobial Agents and ChemotherapyAmerican Society For Microbiology

Published: Nov 1, 2010

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