-
M.
Ivan,
K.
Kondo,
H.
Yang,
W.
Kim,
J.
Valiando,
M.
Ohh,
A.
Salic,
J.
Asara,
William
Lane,
W.
Kaelin
(2001)
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing
Science, 292
-
Cheng-Jun
Hu,
Liyi
Wang,
Lewis
Chodosh,
B.
Keith,
M.
Simon
(2003)
Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation
Molecular and Cellular Biology, 23
-
Zirong
Li,
Sara
Calcar,
Chunxu
Qu,
W.
Cavenee,
Michael
Zhang,
B.
Ren
(2003)
A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells
Proceedings of the National Academy of Sciences of the United States of America, 100
-
N.
Mazure,
C.
Chauvet,
B.
Bois-Joyeux,
Marguerite-Anne
Bernard,
H.
Nacer-Chérif,
J.
Danan
(2002)
Repression of alpha-fetoprotein gene expression under hypoxic conditions in human hepatoma cells: characterization of a negative hypoxia response element that mediates opposite effects of hypoxia inducible factor-1 and c-Myc.
Cancer research, 62 4
-
R.
Gatenby,
R.
Gillies
(2004)
Why do cancers have high aerobic glycolysis?
Nature Reviews Cancer, 4
-
D.
Parry,
P.
Pedersen
(1983)
Intracellular localization and properties of particulate hexokinase in the Novikoff ascites tumor. Evidence for an outer mitochondrial membrane location.
The Journal of biological chemistry, 258 18
-
A.
Orian,
A.
Orian,
Satkiran
Grewal,
Paul
Knoepfler,
Bruce
Edgar,
S.
Parkhurst,
Robert
Eisenman
(2005)
Genomic binding and transcriptional regulation by the Drosophila Myc and Mnt transcription factors.
Cold Spring Harbor symposia on quantitative biology, 70
-
I.
Papandreou,
R.
Cairns,
Lucrezia
Fontana,
A.
Lim,
N.
Denko
(2006)
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption.
Cell metabolism, 3 3
-
K.
Covello,
James
Kehler,
Hongwei
Yu,
J.
Gordan,
A.
Arsham,
Cheng-Jun
Hu,
P.
Labosky,
M.
Simon,
B.
Keith
(2006)
HIF-2 (cid:1) regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth
-
N.
Danial,
C.
Gramm,
L.
Scorrano,
Chen-Yu
Zhang,
S.
Krauss,
A.
Ranger,
S.
Datta,
M.
Greenberg,
L.
Licklider,
B.
Lowell,
S.
Gygi,
S.
Korsmeyer
(2003)
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
Nature, 424
-
A.
Giaccia,
M.
Simon,
Randall
Johnson
(2004)
The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease.
Genes & development, 18 18
-
T.
Baudino,
C.
Mckay,
Hélène
Pendeville-Samain,
J.
Nilsson,
K.
Maclean,
Elsie
White,
A.
Davis,
J.
Ihle,
J.
Cleveland
(2002)
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression.
Genes & development, 16 19
-
Guang-lei
Wang,
G.
Semenza
(1993)
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
Proceedings of the National Academy of Sciences of the United States of America, 90
-
Sovana
Adhikary,
M.
Eilers
(2005)
Transcriptional regulation and transformation by Myc proteins
Nature Reviews Molecular Cell Biology, 6
-
S.
Weinhouse
(1956)
On respiratory impairment in cancer cells.
Science, 124 3215
-
J.
Rathmell,
C.
Fox,
D.
Plas,
P.
Hammerman,
Ryan
Cinalli,
C.
Thompson
(2003)
Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival
Molecular and Cellular Biology, 23
-
P.
Gao,
Huafeng
Zhang,
Ramani
Dinavahi,
Feng
Li,
Yan
Xiang,
V.
Raman,
Z.
Bhujwalla,
D.
Felsher,
Linzhao
Cheng,
J.
Pevsner,
Linda
Lee,
G.
Semenza,
C.
Dang
(2007)
HIF-dependent antitumorigenic effect of antioxidants in vivo.
Cancer cell, 12 3
-
J.
Gordan,
Jessica
Bertout,
Cheng-Jun
Hu,
J.
Diehl,
M.
Simon,
M.
Simon
(2007)
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity.
Cancer cell, 11 4
-
Shiva
Golshani-Hebroni,
S.
Bessman
(1997)
Hexokinase Binding to Mitochondria: A Basis for Proliferative Energy Metabolism
Journal of Bioenergetics and Biomembranes, 29
-
(1999)
The Myc oncoprotein: a critical VOL
-
C.
Nesbit,
J.
Tersak,
E.
Prochownik
(1999)
MYC oncogenes and human neoplastic disease
Oncogene, 18
-
Kenneth
To,
M.
Koshiji,
S.
Hammer,
L.
Huang
(2005)
Genetic Instability: The Dark Side of THE Hypoxic Response
Cell Cycle, 4
-
W.
Hon,
Michael
Wilson,
K.
Harlos,
T.
Claridge,
C.
Schofield,
C.
Pugh,
P.
Maxwell,
P.
Ratcliffe,
D.
Stuart,
E.
Jones
(2002)
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
Nature, 417 6892
-
Jung-whan
Kim,
C.
Dang
(2006)
Cancer's molecular sweet tooth and the Warburg effect.
Cancer research, 66 18
-
Nathan
Majewski,
V.
Nogueira,
R.
Robey,
N.
Hay
(2004)
Akt Inhibits Apoptosis Downstream of BID Cleavage via a Glucose-Dependent Mechanism Involving Mitochondrial Hexokinases
Molecular and Cellular Biology, 24
-
Lawrence
Gardner,
Qing
Li,
Michele
Park,
W.
Flanagan,
G.
Semenza,
C.
Dang
(2001)
Hypoxia Inhibits G1/S Transition through Regulation of p27 Expression*
The Journal of Biological Chemistry, 276
-
P.
O’Farrell
(2001)
Faculty Opinions recommendation of Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
-
Jo
Forsythe,
B.
Jiang,
N.
Iyer,
F.
Agani,
S.
Leung,
R.
Koos,
G.
Semenza
(1996)
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
Molecular and Cellular Biology, 16
-
P.
Gao,
Huafeng
Zhang,
Ramani
Dinavahi,
Feng
Li,
Yan
Xiang,
V.
Raman,
Z.
Bhujwalla,
D.
Felsher,
Linzhao
Cheng,
J.
Pevsner,
A.
Linda,
Lee,
G.
Semenza,
C.
Dang
(2007)
HIF-dependent Anti-tumorigenic Effect of Anti-oxidants In Vivo
-
Paul
Corn,
M.
Ricci,
K.
Scata,
A.
Arsham,
M.
Simon,
D.
Dicker,
W.
El-Deiry
(2005)
Mxi1 is induced by hypoxia in a HIF-1–dependent manner and protects cells from c-Myc-induced apoptosis
Cancer Biology & Therapy, 4
-
Kathrin
Gottlob,
Nathan
Majewski,
S.
Kennedy,
S.
Kennedy,
E.
Kandel,
R.
Robey,
N.
Hay
(2001)
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase.
Genes & development, 15 11
-
Ulrike
Knies-Bamforth,
S.
Fox,
R.
Poulsom,
G.
Evan,
A.
Harris
(2004)
c-Myc Interacts with Hypoxia to Induce Angiogenesis In vivo by a Vascular Endothelial Growth Factor-Dependent Mechanism
Cancer Research, 64
-
M.
Koshiji,
Kenneth
To,
S.
Hammer,
K.
Kumamoto,
A.
Harris,
P.
Modrich,
L.
Huang
(2005)
HIF-1α Induces Genetic Instability by Transcriptionally Downregulating MutSα Expression
Molecular Cell, 17
-
K.
Kondo,
J.
Klco,
E.
Nakamura,
M.
Lechpammer,
W.
Kaelin
(2002)
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.
Cancer cell, 1 3
-
Emin
Maltepe,
Simon
Mc
(1998)
Oxygen, genes, and development: An analysis of the role of hypoxic gene regulation during murine vascular development
Journal of Molecular Medicine, 76
-
B.
Krishnamachary,
D.
Zagzag,
H.
Nagasawa,
K.
Rainey,
H.
Okuyama,
J.
Baek,
G.
Semenza
(2006)
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.
Cancer research, 66 5
-
K.
Covello,
M.
Simon,
B.
Keith
(2005)
Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth.
Cancer research, 65 6
-
H.
Ryan,
J.
Lo,
R.
Johnson
(1998)
HIF‐1α is required for solid tumor formation and embryonic vascularization
The EMBO Journal, 17
-
Thi
Bui,
C.
Thompson
(2006)
Cancer's sweet tooth.
Cancer cell, 9 6
-
K.
Zeller,
X.
Zhao,
C.
Lee,
K.
Chiu,
Fei
Yao,
J.
Yustein,
H.
Ooi,
Y.
Orlov,
A.
Shahab,
H.
Yong,
Yutao
Fu,
Z.
Weng,
V.
Kuznetsov,
W.
Sung,
Y.
Ruan,
C.
Dang,
Chia-Lin
Wei
(2006)
Global mapping of c-Myc binding sites and target gene networks in human B cells
Proceedings of the National Academy of Sciences, 103
-
M.
Koshiji,
L.
Huang
(2004)
Dynamic Balancing of the Dual Nature of HIF-1alpha for Cell Survival
Cell Cycle, 3
-
C.
Dang
(1999)
c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism
Molecular and Cellular Biology, 19
-
N.
Goda,
H.
Ryan,
B.
Khadivi,
W.
McNulty,
R.
Rickert,
Randall
Johnson
(2002)
Hypoxia-Inducible Factor 1 (cid:2) Is Essential for Cell Cycle Arrest during Hypoxia
-
M.
Schuhmacher,
M.
Staege,
A.
Pajic,
A.
Polack,
U.
Weidle,
G.
Bornkamm,
D.
Eick,
F.
Kohlhuber
(1999)
Control of cell growth by c-Myc in the absence of cell division
Current Biology, 9
-
Ksenya
Shchors,
E.
Shchors,
Fanya
Rostker,
E.
Lawlor,
L.
Brown-Swigart,
G.
Evan
(2006)
The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta.
Genes & development, 20 18
-
Feng
Li,
Yunyue
Wang,
K.
Zeller,
J.
Potter,
Diane
Wonsey,
Kathryn
O’Donnell,
Jung-whan
Kim,
J.
Yustein,
Linda
Lee,
C.
Dang
(2005)
Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis
Molecular and Cellular Biology, 25
-
Robert
Eisenman
(2001)
Deconstructing myc.
Genes & development, 15 16
-
S.
Bonnet,
S.
Archer,
J.
Allalunis-Turner,
A.
Haromy,
C.
Beaulieu,
Richard
Thompson,
Christopher
Lee,
G.
Lopaschuk,
L.
Puttagunta,
Sandra
Bonnet,
Gwyneth
Harry,
K.
Hashimoto,
C.
Porter,
M.
Andrade,
B.
Thébaud,
E.
Michelakis
(2007)
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.
Cancer cell, 11 1
-
E.
Berra,
E.
Benizri,
A.
Ginouvès,
Véronique
Volmat,
D.
Roux,
J.
Pouysségur
(2003)
HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia
The EMBO Journal, 22
-
N.
Masson,
C.
Willam,
P.
Maxwell,
C.
Pugh,
P.
Ratcliffe
(2001)
Independent function of two destruction domains in hypoxia‐inducible factor‐α chains activated by prolyl hydroxylation
The EMBO Journal, 20
-
M.
Holness,
M.
Sugden
(2003)
Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation.
Biochemical Society transactions, 31 Pt 6
-
H.
Tian,
S.
McKnight,
D.
Russell
(1997)
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.
Genes & development, 11 1
-
C.
Schofield,
P.
Ratcliffe
(2004)
Oxygen sensing by HIF hydroxylases
Nature Reviews Molecular Cell Biology, 5
-
A.
Pajic,
D.
Spitkovsky,
B.
Christoph,
B.
Kempkes,
M.
Schuhmacher,
M.
Staege,
M.
Brielmeier,
J.
Ellwart,
F.
Kohlhuber,
G.
Bornkamm,
A.
Polack,
D.
Eick
(2000)
Cell cycle activation by c‐myc in a Burkitt lymphoma model cell line
International Journal of Cancer, 87
-
A.
Giaccia,
B.
Siim,
R.
Johnson
(2003)
HIF-1 as a target for drug development
Nature Reviews Drug Discovery, 2
-
J.
Pastorino,
J.
Hoek
(2003)
Hexokinase II: the integration of energy metabolism and control of apoptosis.
Current medicinal chemistry, 10 16
-
G.
Semenza
(2003)
Targeting HIF-1 for cancer therapy
Nature Reviews Cancer, 3
-
K.
Covello,
J.
Kehler,
Hongwei
Yu,
J.
Gordan,
A.
Arsham,
Cheng-Jun
Hu,
P.
Labosky,
M.
Simon,
B.
Keith
(2006)
HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.
Genes & development, 20 5
-
H.
Shim,
C.
Dolde,
B.
Lewis,
C.
Wu,
Gerard
Dang,
R.
Jungmann,
R.
Dalla-Favera,
C.
Dang
(1997)
c-Myc transactivation of LDH-A: implications for tumor metabolism and growth.
Proceedings of the National Academy of Sciences of the United States of America, 94 13
-
O.
Warburg
(1956)
[Origin of cancer cells].
Oncologia, 9 2
-
M.
Brahimi-Horn,
J.
Chiche,
J.
Pouysségur
(2007)
Hypoxia signalling controls metabolic demand.
Current opinion in cell biology, 19 2
-
H.
Ryan,
J.
Lo,
R.
Johnson
(1998)
HIF-1 alpha is required for solid tumor formation and embryonic vascularization.
The EMBO journal, 17 11
-
William
Kim,
M.
Safran,
Marshall
Buckley,
B.
Ebert,
J.
Glickman,
M.
Bosenberg,
Meredith
Regan,
W.
Kaelin
(2006)
Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo.
The EMBO journal, 25 19
-
Ksenya
Shchors,
E.
Shchors,
Fanya
Rostker,
E.
Lawlor,
L.
Brown-Swigart,
G.
Evan
(2006)
The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1 (cid:1)
-
R.
Ponzielli,
Sigal
Katz,
D.
Barsyte-Lovejoy,
L.
Penn
(2005)
Cancer therapeutics: targeting the dark side of Myc.
European journal of cancer, 41 16
-
G.
Semenza,
P.
Roth,
H
Fang,
G.
Wang
(1994)
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.
The Journal of biological chemistry, 269 38
-
Jung-whan
Kim,
Irina
Tchernyshyov,
G.
Semenza,
C.
Dang
(2006)
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.
Cell metabolism, 3 3
-
G.
Semenza
(2001)
HIF-1, O2, and the 3 PHDs How Animal Cells Signal Hypoxia to the Nucleus
Cell, 107
-
William
Kim,
M.
Safran,
Marshall
Buckley,
B.
Ebert,
J.
Glickman,
M.
Bosenberg,
Meredith
Regan,
W.
Kaelin
(2006)
Failure to prolyl hydroxylate hypoxia‐inducible factor α phenocopies VHL inactivation in vivo
The EMBO Journal, 25
-
G.
Semenza
(2002)
HIF-1 and tumor progression: pathophysiology and therapeutics.
Trends in molecular medicine, 8 4 Suppl
-
J.
Pastorino,
N.
Shulga,
J.
Hoek
(2002)
Mitochondrial Binding of Hexokinase II Inhibits Bax-induced Cytochrome c Release and Apoptosis*
The Journal of Biological Chemistry, 277
-
B.
Kelly,
S.
Hackett,
K.
Hirota,
Y.
Oshima,
Z.
Cai,
S.
Berg-Dixon,
Ashley
Rowan,
Zhijiang
Yan,
P.
Campochiaro,
G.
Semenza
(2003)
Cell Type–Specific Regulation of Angiogenic Growth Factor Gene Expression and Induction of Angiogenesis in Nonischemic Tissue by a Constitutively Active Form of Hypoxia-Inducible Factor 1
Circulation Research: Journal of the American Heart Association, 93
-
M.
Cole,
S.
McMahon
(1999)
The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation
Oncogene, 18
-
N.
Mazure,
C.
Chauvet,
B.
Bois-Joyeux,
Marguerite-Anne
Bernard,
H.
Nacer-Chérif,
J.
Danan
(2002)
Repression of α-Fetoprotein Gene Expression under Hypoxic Conditions in Human Hepatoma Cells: Characterization of a Negative Hypoxia Response Element That Mediates Opposite Effects of Hypoxia Inducible Factor-1 and c-Myc
Cancer Research, 62
-
Rebecca
Osthus,
Hyunsuk
Shim,
Sunkyu
Kim,
Qing
Li,
R.
Reddy,
Mita
Mukherjee,
Yi
Xu,
Diane
Wonsey,
Linda
Lee,
C.
Dang
(2000)
Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc*
The Journal of Biological Chemistry, 275
-
John
Gordan,
M.
Simon
(2007)
Hypoxia-inducible factors: central regulators of the tumor phenotype.
Current opinion in genetics & development, 17 1
-
Jung-Hyun
Min,
Haifeng
Yang,
M.
Ivan,
F.
Gertler,
W.
Kaelin,
N.
Pavletich
(2002)
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling
Science, 296
-
R.
Shaw
(2006)
Glucose metabolism and cancer.
Current opinion in cell biology, 18 6
-
C.
Pugh,
P.
Ratcliffe
(2003)
Regulation of angiogenesis by hypoxia: role of the HIF system
Nature Medicine, 9
-
M.
Koshiji,
Y.
Kageyama,
Erin
Pete,
I.
Horikawa,
J.
Barrett,
L.
Huang
(2004)
HIF‐1α induces cell cycle arrest by functionally counteracting Myc
The EMBO Journal, 23
-
V.
Fantin,
J.
St-Pierre,
P.
Leder
(2006)
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance.
Cancer cell, 9 6
-
H.
Ashrafian
(2006)
Cancer's sweet tooth: the Janus effect of glucose metabolism in tumorigenesis
The Lancet, 367
-
Liping
Liu,
T.
Cash,
Russell
Jones,
B.
Keith,
C.
Thompson,
M.
Simon
(2006)
Hypoxia-induced energy stress regulates mRNA translation and cell growth.
Molecular cell, 21 4
-
M.
Mateyak,
A.
Obaya,
Susumu
Adachi,
J.
Sedivy
(1997)
Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 8 10
-
Jung-whan
Kim,
K.
Zeller,
Yunyue
Wang,
A.
Jegga,
B.
Aronow,
Kathryn
O’Donnell,
C.
Dang
(2004)
Evaluation of Myc E-Box Phylogenetic Footprints in Glycolytic Genes by Chromatin Immunoprecipitation Assays
Molecular and Cellular Biology, 24
-
(2001)
Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions
-
Carla
Grandori,
R.
Eisenman
(1997)
Myc target genes.
Trends in biochemical sciences, 22 5
-
S.
Pelengaris,
Michael
Khan,
G.
Evan
(2002)
c-MYC: more than just a matter of life and death
Nature Reviews Cancer, 2
-
A.
Hueber,
G.
Evan
(1998)
Traps to catch unwary oncogenes.
Trends in genetics : TIG, 14 9
-
Huafeng
Zhang,
P.
Gao,
R.
Fukuda,
G.
Kumar,
B.
Krishnamachary,
K.
Zeller,
C.
Dang,
G.
Semenza
(2007)
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity.
Cancer cell, 11 5
-
J.
Maranchie,
J.
Vasselli,
J.
Riss,
J.
Bonifacino,
W.
Linehan,
R.
Klausner
(2002)
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma.
Cancer cell, 1 3