-
R.
Zwart,
L.
Broos,
G.
Grosveld,
D.
Meijer
(1996)
The restricted expression pattern of the POU factor Oct-6 during early development of the mouse nervous system
Mechanisms of Development, 54
-
Huma
Shamim,
I.
Mason
(1998)
Expression of Gbx-2 during early development of the chick embryo
Mechanisms of Development, 76
-
A.
Schier,
W.
Gehring
(1993)
Functional specificity of the homeodomain protein fushi tarazu: the role of DNA-binding specificity in vivo.
Proceedings of the National Academy of Sciences of the United States of America, 90
-
A.
Bubnoff,
Jennifer
Schmidt,
D.
Kimelman
(1996)
TheXenopus laevis homeo☐ geneXgbx-2 is an early marker of anteroposterior patterning in the ectoderm
Mechanisms of Development, 54
-
E.
Jho,
Tong
Zhang,
C.
Domon,
C.
Joo,
J.
Freund,
F.
Costantini
(2002)
Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway
Molecular and Cellular Biology, 22
-
V.
Broccoli,
E.
Boncinelli,
W.
Wurst
(1999)
The caudal limit of Otx2 expression positions the isthmic organizer
Nature, 401
-
Silvia
Maretto,
M.
Cordenonsi,
S.
Dupont,
P.
Braghetta,
V.
Broccoli,
A.
Hassan,
D.
Volpin,
G.
Bressan,
S.
Piccolo
(2003)
Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors
Proceedings of the National Academy of Sciences of the United States of America, 100
-
J.
Bermingham,
S.
Scherer,
S.
O'Connell,
E.
Arroyo,
Kristin
Kalla,
F.
Powell,
M.
Rosenfeld
(1996)
Tst-1/Oct-6/SCIP regulates a unique step in peripheral myelination and is required for normal respiration.
Genes & development, 10 14
-
D.
Mihailescu,
P.
Küry,
D.
Monard
(1999)
An octamer-binding site is crucial for the activity of an enhancer active at the embryonic met-/mesencephalic junction
Mechanisms of Development, 84
-
D.
Acampora,
V.
Avantaggiato,
F.
Tuorto,
A.
Simeone
(1997)
Genetic control of brain morphogenesis through Otx gene dosage requirement.
Development, 124 18
-
Isabelle
Foucher,
M.
Mione,
A.
Simeone,
D.
Acampora,
L.
Bally-Cuif,
C.
Houart
(2006)
Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants
, 133
-
P.
Spaniol,
C.
Bornmann,
G.
Hauptmann,
T.
Gerster
(1996)
Class III POU genes of zebrafish are predominantly expressed in the central nervous system.
Nucleic acids research, 24 24
-
D.
Acampora,
V.
Avantaggiato,
F.
Tuorto,
P.
Barone,
M.
Perera,
D.
Choo,
D.
Wu,
G.
Corte,
A.
Simeone
(1999)
Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes.
Development, 126 7
-
K.
Niss,
A.
Leutz
(1998)
Expression of the homeobox gene GBX2 during chicken development
Mechanisms of Development, 76
-
N.
Suzuki,
H.
Rohdewohld,
T.
Neuman,
Peter
Gruss,
H.
Schöler
(1990)
Oct‐6: a POU transcription factor expressed in embryonal stem cells and in the developing brain.
The EMBO Journal, 9
-
T.
Svingen,
Cassy
Spiller,
K.
Kashimada,
V.
Harley,
P.
Koopman
(2009)
Identification of Suitable Normalizing Genes for Quantitative Real-Time RT-PCR Analysis of Gene Expression in Fetal Mouse Gonads
Sexual Development, 3
-
O.
Minowa,
K.
Ikeda,
Yoshinobu
Sugitani,
T.
Oshima,
Shigeyasu
Nakai,
Y.
Katori,
Masaaki
Suzuki,
M.
Furukawa,
T.
Kawase,
Y.
Zheng,
M.
Ogura,
Y.
Asada,
K.
Watanabe,
H.
Yamanaka,
S.
Gotoh,
M.
Nishi-Takeshima,
T.
Sugimoto,
T.
Kikuchi,
T.
Takasaka,
T.
Noda
(1999)
Altered cochlear fibrocytes in a mouse model of DFN3 nonsyndromic deafness.
Science, 285 5432
-
M.
Baltzinger,
F.
Relaix,
P.
Remy
(1996)
Transcription of XLPOU3, a brain-specific gene, during Xenopus laevis early embryogenesis
Mechanisms of Development, 58
-
T.
Katahira,
Tatsuya
Sato,
S.
Sugiyama,
T.
Okafuji,
I.
Araki,
J.
Funahashi,
Harukazu
Nakamura
(2000)
Interaction between Otx2 and Gbx2 defines the organizing center for the optic tectum
Mechanisms of Development, 91
-
D.
Kurokawa,
Tomomi
Ohmura,
H.
Ogino,
Masaki
Takeuchi,
A.
Inoue,
Fumitaka
Inoue,
Y.
Suda,
S.
Aizawa
(2010)
Evolutionary origin of the Otx2 enhancer for its expression in visceral endoderm.
Developmental biology, 342 1
-
Thomas
Heimbucher,
Christina
Murko,
B.
Bajoghli,
N.
Aghaallaei,
A.
Huber,
Ronald
Stebegg,
D.
Eberhard,
M.
Fink,
A.
Simeone,
T.
Czerny
(2006)
Gbx2 and Otx2 Interact with the WD40 Domain of Groucho/Tle Corepressors
Molecular and Cellular Biology, 27
-
Yusuke
Sakurai,
D.
Kurokawa,
H.
Kiyonari,
Eriko
Kajikawa,
Y.
Suda,
S.
Aizawa
(2010)
Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization.
Developmental biology, 347 2
-
Md.
Islam,
H.
Kikuta,
Fumitaka
Inoue,
M.
Kanai,
A.
Kawakami,
M.
Parvin,
H.
Takeda,
K.
Yamasu
(2006)
Three enhancer regions regulate gbx2 gene expression in the isthmic region during zebrafish development
Mechanisms of Development, 123
-
A.
Joyner,
Aimin
Liu,
S.
Millet
(2000)
Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer.
Current opinion in cell biology, 12 6
-
Shigeyasu
Nakai,
Hitoshi
Kawano,
Tamaki
Yudate,
Miyuki
Nishi,
J.
Kuno,
A.
Nagata,
K.
Jishage,
Hiroshi
Hamada,
Hideta
Fujii,
Koki
Kawamura,
Kiyotaka
Shiba,
Tetsuo
Noda
(1995)
The POU domain transcription factor Brn-2 is required for the determination of specific neuronal lineages in the hypothalamus of the mouse.
Genes & development, 9 24
-
A.
Bulfone,
L.
Puelles,
M.
Porteus,
M.
Frohman,
G.
Martin,
J.
Rubenstein
(1993)
Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt- 3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries
, 13
-
D.
Kurokawa,
H.
Kiyonari,
Rika
Nakayama,
Chiharu
Kimura-Yoshida,
I.
Matsuo,
S.
Aizawa
(2004)
Regulation of Otx2 expression and its functions in mouse forebrain and midbrain
, 131
-
James
Li,
Zhimin
Lao,
A.
Joyner
(2002)
Changing Requirements for Gbx2 in Development of the Cerebellum and Maintenance of the Mid/Hindbrain Organizer
Neuron, 36
-
H.
Kikuta,
M.
Kanai,
Yuki
Ito,
K.
Yamasu
(2003)
gbx2 Homeobox gene is required for the maintenance of the isthmic region in the zebrafish embryonic brain
Developmental Dynamics, 228
-
H.
Okazawa,
I.
Imafuku,
M.
Minowa,
I.
Kanazawa,
H.
Hamada,
M.
Mouradian
(1996)
Regulation of striatal D1A dopamine receptor gene transcription by Brn-4.
Proceedings of the National Academy of Sciences of the United States of America, 93 21
-
Po,
HE
Xi,
Renee
Gerrero,
Donna
Simmons,
Ronald
Park,
'.
Lin,
Larry
Swanson,
Michael
Rosenfeld
(1991)
Tst-1, a member of the POU domain gene family, binds the promoter of the gene encoding the cell surface adhesion molecule P0
Molecular and Cellular Biology, 11
-
D.
Kobi,
Anne-Lise
Steunou,
D.
Dembélé,
S.
Legras,
L.
Larue,
Laurence
Nieto,
I.
Davidson
(2010)
Genome‐wide analysis of POU3F2/BRN2 promoter occupancy in human melanoma cells reveals Kitl as a novel regulated target gene
Pigment Cell & Melanoma Research, 23
-
Yoshinobu
Sugitani,
Shigeyasu
Nakai,
O.
Minowa,
M.
Nishi,
K.
Jishage,
H.
Kawano,
K.
Mori,
M.
Ogawa,
T.
Noda
(2002)
Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons.
Genes & development, 16 14
-
Antonio
Simeone,
Antonio
Simeone
(2000)
Positioning the isthmic organizer where Otx2 and Gbx2meet.
Trends in genetics : TIG, 16 6
-
M.
Hirano,
S.
Hashimoto,
S.
Yonemura,
H.
Sabe,
S.
Aizawa
(2008)
EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial–mesenchymal transition
The Journal of Cell Biology, 182
-
Martin
Billeter
(1996)
Homeodomain-type DNA recognition.
Progress in biophysics and molecular biology, 66 3
-
Peng
Li,
Xi
He,
M.
Gerrero,
M.
Mok,
A.
Aggarwal,
M.
Rosenfeld,
G.
Chaconas,
Andrei
Constantinescu,
Terri
Morrow,
A.
Peng,
B.
Lichte,
D.
Maier,
T.
Schneider,
J.
Manfredi,
D.
Marshak,
C.
Prives,
Mary
Anderson,
J.
Schwedes
(1993)
Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors.
Genes & development, 7 12B
-
G.
Hauptmann,
T.
Gerster
(2000)
Combinatorial expression of zebrafish Brn‐1‐ and Brn‐2‐related POU genes in the embryonic brain, pronephric primordium, and pharyngeal arches
Developmental Dynamics, 218
-
A.
Garda,
D.
Echevarrı́a,
S.
Martinez
(2001)
Neuroepithelial co-expression of Gbx2 and Otx2 precedes Fgf8 expression in the isthmic organizer
Mechanisms of Development, 101
-
M.
Hidalgo-Sánchez,
A.
Simeone,
R.
Alvarado-Mallart
(1999)
Fgf8 and Gbx2 induction concomitant with Otx2 repression is correlated with midbrain-hindbrain fate of caudal prosencephalon.
Development, 126 14
-
Ella
Tour,
G.
Pillemer,
Y.
Gruenbaum,
A.
Fainsod
(2002)
Gbx2 interacts with Otx2 and patterns the anterior–posterior axis during gastrulation in Xenopus
Mechanisms of Development, 112
-
R.
Herrscher,
M.
Kaplan,
M.
Kaplan,
D.
Lelsz,
Chhaya
Das,
Chhaya
Das,
R.
Scheuermann,
P.
Tucker,
P.
Tucker
(1995)
The immunoglobulin heavy-chain matrix-associating regions are bound by Bright: a B cell-specific trans-activator that describes a new DNA-binding protein family.
Genes & development, 9 24
-
V.
Agarwal,
S.
Sato
(1991)
XLPOU 1 and XLPOU 2, two novel POU domain genes expressed in the dorsoanterior region of Xenopus embryos.
Developmental biology, 147 2
-
Ella
Tour,
G.
Pillemer,
Y.
Gruenbaum,
A.
Fainsod
(2002)
Otx2 can activate the isthmic organizer genetic network in the Xenopus embryo
Mechanisms of Development, 110
-
S.
Millet,
K.
Campbell,
D.
Epstein,
K.
Losos,
E.
Harris,
A.
Joyner
(1999)
A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer
Nature, 401
-
D.
Kurokawa,
N.
Takasaki,
H.
Kiyonari,
Rika
Nakayama,
Chiharu
Kimura-Yoshida,
I.
Matsuo,
S.
Aizawa
(2004)
Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm
, 131
-
J.
Patton,
E.
Porro,
Juan
Galceran,
P.
Tempst,
B.
Nadal-Ginard
(1993)
Cloning and characterization of PSF, a novel pre-mRNA splicing factor.
Genes & development, 7 3
-
Y.
Suda,
K.
Kokura,
J.
Kimura,
Eriko
Kajikawa,
Fumitaka
Inoue,
S.
Aizawa
(2010)
The same enhancer regulates the earliest Emx2 expression in caudal forebrain primordium, subsequent expression in dorsal telencephalon and later expression in the cortical ventricular zone
Development, 137
-
Zsuzsa
Agoston,
D.
Schulte
(2009)
Meis2 competes with the Groucho co-repressor Tle4 for binding to Otx2 and specifies tectal fate without induction of a secondary midbrain-hindbrain boundary organizer
Development, 136
-
N.
Takasaki,
D.
Kurokawa,
Rika
Nakayama,
J.
Nakayama,
S.
Aizawa
(2007)
Acetylated YY1 regulates Otx2 expression in anterior neuroectoderm at two cis‐sites 90 kb apart
The EMBO Journal, 26
-
Xi
He,
M.
Treacy,
D.
Simmons,
H.
Ingraham,
L.
Swanson,
M.
Rosenfeld
(1989)
Expression of a large family of POU-domain regulatory genes in mammalian brain development
Nature, 340
-
M.
Wierman,
Xiaoyan
Xiong,
J.
Kepa,
A.
Spaulding,
Britta
Jacobsen,
Z.
Fang,
Gajanan
Nilaver,
Sergio
Ojeda
(1997)
Repression of gonadotropin-releasing hormone promoter activity by the POU homeodomain transcription factor SCIP/Oct-6/Tst-1: a regulatory mechanism of phenotype expression?
Molecular and Cellular Biology, 17
-
D.
Meijer,
A.
Graus,
R.
Kraay,
A.
Langeveld,
M.
Mulder,
G.
Grosveld
(1990)
The octamer binding factor Oct6: cDNA cloning and expression in early embryonic cells.
Nucleic acids research, 18 24
-
C.
Verrijzer,
Mark
Alkema,
W.
Weperen,
H.
Leeuwen,
M.
Strating,
P.
Vliet
(1992)
The DNA binding specificity of the bipartite POU domain and its subdomains.
The EMBO Journal, 11
-
Tatsuya
Sato,
I.
Araki,
Harukazu
Nakamura
(2001)
Inductive signal and tissue responsiveness defining the tectum and the cerebellum.
Development, 128 13
-
J.
Rhee,
Craig
Gruber,
T.
Brodie,
M.
Trieu,
E.
Turner
(1998)
Highly Cooperative Homodimerization Is a Conserved Property of Neural POU Proteins*
The Journal of Biological Chemistry, 273
-
D.
Kurokawa,
Yusuke
Sakurai,
A.
Inoue,
Rika
Nakayama,
N.
Takasaki,
Y.
Suda,
T.
Miyake,
C.
Amemiya,
S.
Aizawa
(2006)
Evolutionary constraint on Otx2 neuroectoderm enhancers-deep conservation from skate to mouse and unique divergence in teleost
Proceedings of the National Academy of Sciences, 103
-
Caihong
Xia,
Chen
Wang,
Kejing
Zhang,
C.
Qian,
N.
Jing
(2007)
Induction of a high population of neural stem cells with anterior neuroectoderm characters from epiblast-like P19 embryonic carcinoma cells.
Differentiation; research in biological diversity, 75 10
-
K.
Wassarman,
M.
Lewandoski,
K.
Campbell,
A.
Joyner,
J.
Rubenstein,
S.
Martinez,
G.
Martin
(1997)
Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function.
Development, 124 15
-
C.
Kimura,
Naoki
Takeda,
Misao
Suzuki,
Mitsuo
Oshimura,
Shinichi
Aizawa,
I.
Matsuo
(1997)
Cis-acting elements conserved between mouse and pufferfish Otx2 genes govern the expression in mesencephalic neural crest cells.
Development, 124 20
-
Bogi
Andersen,
Michael
Rosenfeld
(2001)
POU domain factors in the neuroendocrine system: lessons from developmental biology provide insights into human disease.
Endocrine reviews, 22 1
-
G.
Hauptmann,
T.
Gerster
(1996)
Complex expression of the zp-50 pou gene in the embryonic zebrafish brain is altered by overexpression of sonic hedgehog.
Development, 122 6
-
Y.
Suda,
I.
Matsuo,
S.
Aizawa
(1997)
Cooperation between Otx1 and Otx2 genes in developmental patterning of rostral brain
Mechanisms of Development, 69
-
R.
Mcevilly,
Marcela
Diaz,
M.
Schonemann,
F.
Hooshmand,
M.
Rosenfeld
(2002)
Transcriptional Regulation of Cortical Neuron Migration by POU Domain Factors
Science, 295
-
Aimin
Liu,
K.
Losos,
A.
Joyner
(1999)
FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate.
Development, 126 21
-
Aimin
Liu,
A.
Joyner
(2001)
EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region.
Development, 128 2
-
R.
Rupp,
L.
Snider,
H.
Weintraub
(1994)
Xenopus embryos regulate the nuclear localization of XMyoD.
Genes & development, 8 11
-
Shigeyasu
Nakai,
Yoshinobu
Sugitani,
Hiroshi
Sato,
S.
Ito,
Y.
Miura,
M.
Ogawa,
M.
Nishi,
K.
Jishage,
O.
Minowa,
T.
Noda
(2003)
Crucial roles of Brn1 in distal tubule formation and function in mouse kidney
, 130