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Dual Spectinomycin-Streptomycin Resistance Marker in Brucella spp.

Dual Spectinomycin-Streptomycin Resistance Marker in Brucella spp. Dual Spectinomycin-Streptomycin Resistance Marker in Brucella spp. Jon P. Woods Department of Medical Microbiology & Immunology University of Wisconsin Madison, Wisconsin 53706-1532 Phone: (608) 265-6292 Fax: (608) 265-6717 E-mail: jpwoods@facstaff.wisc.edu Pathogenic microbiology investigators have a responsibility to consider the public health implications of their research, including the experimental introduction of antibiotic resistance markers that could influence the treatment of infectious diseases. Furthermore, the reviewers for Infection and Immunity as well as other scientific journals are asked to evaluate submitted manuscripts for the occurrence of “misuses of microbiology or of information derived from microbiology”( 1 ). But the importance of resistance to multiple antibiotics conferred by single marker genes is not always recognized. A case in point is the bacterial aadA1 gene in the omega fragment, originally from plasmid R100.1 ( 6 ). The use of this marker has recently been reported for gene disruption in Brucella suis with selection for resistance against spectinomycin, an antibiotic not used in the treatment of brucellosis ( 5 ). However, this marker also confers resistance to streptomycin, a frontline antibiotic frequently included in therapeutic protocols for brucellosis ( 2 ). This point may be particularly important for this organism due to its http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Infection and Immunity American Society For Microbiology

Dual Spectinomycin-Streptomycin Resistance Marker in Brucella spp.

Infection and Immunity , Volume 76 (7): 3357 – Jul 1, 2008

Dual Spectinomycin-Streptomycin Resistance Marker in Brucella spp.

Infection and Immunity , Volume 76 (7): 3357 – Jul 1, 2008

Abstract

Dual Spectinomycin-Streptomycin Resistance Marker in Brucella spp. Jon P. Woods Department of Medical Microbiology & Immunology University of Wisconsin Madison, Wisconsin 53706-1532 Phone: (608) 265-6292 Fax: (608) 265-6717 E-mail: jpwoods@facstaff.wisc.edu Pathogenic microbiology investigators have a responsibility to consider the public health implications of their research, including the experimental introduction of antibiotic resistance markers that could influence the treatment of infectious diseases. Furthermore, the reviewers for Infection and Immunity as well as other scientific journals are asked to evaluate submitted manuscripts for the occurrence of “misuses of microbiology or of information derived from microbiology”( 1 ). But the importance of resistance to multiple antibiotics conferred by single marker genes is not always recognized. A case in point is the bacterial aadA1 gene in the omega fragment, originally from plasmid R100.1 ( 6 ). The use of this marker has recently been reported for gene disruption in Brucella suis with selection for resistance against spectinomycin, an antibiotic not used in the treatment of brucellosis ( 5 ). However, this marker also confers resistance to streptomycin, a frontline antibiotic frequently included in therapeutic protocols for brucellosis ( 2 ). This point may be particularly important for this organism due to its

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Publisher
American Society For Microbiology
Copyright
Copyright © 2008 by the American society for Microbiology.
ISSN
0019-9567
eISSN
1098-5522
DOI
10.1128/IAI.00479-08
pmid
18565907
Publisher site
See Article on Publisher Site

Abstract

Dual Spectinomycin-Streptomycin Resistance Marker in Brucella spp. Jon P. Woods Department of Medical Microbiology & Immunology University of Wisconsin Madison, Wisconsin 53706-1532 Phone: (608) 265-6292 Fax: (608) 265-6717 E-mail: jpwoods@facstaff.wisc.edu Pathogenic microbiology investigators have a responsibility to consider the public health implications of their research, including the experimental introduction of antibiotic resistance markers that could influence the treatment of infectious diseases. Furthermore, the reviewers for Infection and Immunity as well as other scientific journals are asked to evaluate submitted manuscripts for the occurrence of “misuses of microbiology or of information derived from microbiology”( 1 ). But the importance of resistance to multiple antibiotics conferred by single marker genes is not always recognized. A case in point is the bacterial aadA1 gene in the omega fragment, originally from plasmid R100.1 ( 6 ). The use of this marker has recently been reported for gene disruption in Brucella suis with selection for resistance against spectinomycin, an antibiotic not used in the treatment of brucellosis ( 5 ). However, this marker also confers resistance to streptomycin, a frontline antibiotic frequently included in therapeutic protocols for brucellosis ( 2 ). This point may be particularly important for this organism due to its

Journal

Infection and ImmunityAmerican Society For Microbiology

Published: Jul 1, 2008

There are no references for this article.