<h2>LETTER</h2> The recent article by Abramczuk et al. is timely ( 1 ). With improving access worldwide to antiretroviral (ARV) therapy, an increasing number of children are born who are human immunodeficiency virus (HIV) exposed but uninfected (HEU). Understanding their specific needs will allow health professionals to tailor care appropriately, making research in this area essential. Although the authors of the above paper allude to antiretroviral use in their discussion, no mention is made of whether the study population was exposed to ARVs in utero . As indicated in the paper, ARV exposure may modulate placental cytokine patterns ( 2 ). It would be useful if the authors could comment upon ARV exposure and regimens used. With regard to the hepatitis B vaccination results (anti-HBs titers), the statistical analysis accompanying Table 1 is a chi-squared test. An assumption of this test is that 80% of the cell counts have an expected frequency of greater than 5. In this case, 33% of the expected cell counts (i.e., 2 out of 6) do not fulfill this assumption. While Fisher's exact test (which could have been used in this circumstance) is significant ( P = 0.003), it is incorrect to state
Do Children Exposed to Human Immunodeficiency Virus but Not Infected Actually Have a More Robust Response to Hepatitis B Vaccination than Their Nonexposed Peers?
Abstract
<h2>LETTER</h2> The recent article by Abramczuk et al. is timely ( 1 ). With improving access worldwide to antiretroviral (ARV) therapy, an increasing number of children are born who are human immunodeficiency virus (HIV) exposed but uninfected (HEU). Understanding their specific needs will allow health professionals to tailor care appropriately, making research in this area essential. Although the authors of the above paper allude to antiretroviral use in their discussion, no mention is made of whether the study population was exposed to ARVs in utero . As indicated in the paper, ARV exposure may modulate placental cytokine patterns ( 2 ). It would be useful if the authors could comment upon ARV exposure and regimens used. With regard to the hepatitis B vaccination results (anti-HBs titers), the statistical analysis accompanying Table 1 is a chi-squared test. An assumption of this test is that 80% of the cell counts have an expected frequency of greater than 5. In this case, 33% of the expected cell counts (i.e., 2 out of 6) do not fulfill this assumption. While Fisher's exact test (which could have been used in this circumstance) is significant ( P = 0.003), it is incorrect to statePreview Only. This article cannot be rented because we do not currently have permission from the publisher.
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Do Children Exposed to Human Immunodeficiency Virus but Not Infected Actually Have a More Robust Response to Hepatitis B Vaccination than Their Nonexposed Peers?
Swann, Olivia; Harrison, Ewen M.
Follow Clinical and Vaccine Immunology
, Volume 19 (2): 293
American Society For Microbiology – Feb 1, 2012
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