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Differences in Interactions between Azole Drugs Related to Modifications in the 14-α Sterol Demethylase Gene (cyp51A) of Aspergillus fumigatus

Differences in Interactions between Azole Drugs Related to Modifications in the 14-α Sterol... Differences in Interactions between Azole Drugs Related to Modifications in the 14-α Sterol Demethylase Gene ( cyp51A ) of Aspergillus fumigatus G. Garcia-Effron , E. Mellado , A. Gomez-Lopez , L. Alcazar-Fuoli , M. Cuenca-Estrella and Juan L. Rodriguez-Tudela * Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain ABSTRACT The combined activity of different azole drugs was investigated. Thirty-one Aspergillus fumigatus strains were tested, including two cyp51A − and one cyp51B − gene-knockout strain and azole-susceptible and -resistant strains with different resistance mechanisms. The combination of itraconazole and voriconazole was synergistic for all strains except for those with gene knockouts. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Antimicrobial Agents and Chemotherapy American Society For Microbiology

Differences in Interactions between Azole Drugs Related to Modifications in the 14-α Sterol Demethylase Gene (cyp51A) of Aspergillus fumigatus

Differences in Interactions between Azole Drugs Related to Modifications in the 14-α Sterol Demethylase Gene (cyp51A) of Aspergillus fumigatus

Antimicrobial Agents and Chemotherapy , Volume 49 (5): 2119 – May 1, 2005

Abstract

Differences in Interactions between Azole Drugs Related to Modifications in the 14-α Sterol Demethylase Gene ( cyp51A ) of Aspergillus fumigatus G. Garcia-Effron , E. Mellado , A. Gomez-Lopez , L. Alcazar-Fuoli , M. Cuenca-Estrella and Juan L. Rodriguez-Tudela * Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain ABSTRACT The combined activity of different azole drugs was investigated. Thirty-one Aspergillus fumigatus strains were tested, including two cyp51A − and one cyp51B − gene-knockout strain and azole-susceptible and -resistant strains with different resistance mechanisms. The combination of itraconazole and voriconazole was synergistic for all strains except for those with gene knockouts.

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References (26)

Publisher
American Society For Microbiology
Copyright
Copyright © 2005 by the American society for Microbiology.
ISSN
0066-4804
eISSN
1098-6596
DOI
10.1128/AAC.49.5.2119-2121.2005
pmid
15855543
Publisher site
See Article on Publisher Site

Abstract

Differences in Interactions between Azole Drugs Related to Modifications in the 14-α Sterol Demethylase Gene ( cyp51A ) of Aspergillus fumigatus G. Garcia-Effron , E. Mellado , A. Gomez-Lopez , L. Alcazar-Fuoli , M. Cuenca-Estrella and Juan L. Rodriguez-Tudela * Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain ABSTRACT The combined activity of different azole drugs was investigated. Thirty-one Aspergillus fumigatus strains were tested, including two cyp51A − and one cyp51B − gene-knockout strain and azole-susceptible and -resistant strains with different resistance mechanisms. The combination of itraconazole and voriconazole was synergistic for all strains except for those with gene knockouts.

Journal

Antimicrobial Agents and ChemotherapyAmerican Society For Microbiology

Published: May 1, 2005

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