Correlation between Antibacterial Power and Chemical Structure of Higher Alkyl Ammonium Ions

Receive: RSS Feeds, eTOCs, free email alerts (when new articles cite this article), more» Information about commercial reprint orders: http://jb.asm.org/site/misc/reprints.xhtml To subscribe to to another ASM Journal go to: http://journals.asm.org/site/subscriptions/ CORRELATION BETWEEN ANTIBACTERLAL POWER AND CHEMICAL STRUCTURE OF ' Onyx Oil and Chemical Company, Jersey City, New Jersey Received for publication July 2, 1945 The relation between the chemical structure and the germicidal efficacy of surface-active cations has been discussed by several investigators (Eldred and Niederl, 1941; Epstein et al., 1943; Jerchel, 1942, 1943; Kolloff et al., 1942; Kuhn et al., 1940, 5 papers; 1941; Rawlins et al., 1943; Shelton et al., 1939, 1940; Westphal, 1941; Woodruff et al., 1942) during the last few years. This paper presents additional data gathered on series of compounds closely related to [ ° C CH, Downloaded from http://jb.asm.org/ on December 9, 2011 by deepdyve CH3 dodecyl dimethyl benzyl ammonium chloride, the first of the quaternary ammonium salts to attain technical significance as a germicide (Domagk, 1935). Contrary to expectations, no extensive data have as yet been published on this group of compounds. In this paper the influence of the chain length of the long hydrocarbon chain and of the nature of the lower alkyl and aralkyl groups is discussed on the basis of the experimental material. EXPERIMENTAL In order to secure reproducible data on germicidal efficacy, it is necessary to standardize the test, including the origin and cultivation of the bacterial strains used. A method which fulfills these conditions is the official or...