Biochemistry of the Leishmania species.
Abstract
Receive: RSS Feeds, eTOCs, free email alerts (when new articles cite this article), more» Downloaded from http://mmbr.asm.org/ on December 24, 2011 by deepdyve Information about commercial reprint orders: http://mmbr.asm.org/site/misc/reprints.xhtml To subscribe to to another ASM Journal go to: http://journals.asm.org/site/subscriptions/ MICROBIOLOGICAL REVIEWS, Dec. 1988, p. 412-432 Vol. 52, No. 4 0146-0749/88/040412-21$02.00/0 Copyright C) 1988, American Society for Microbiology ROBERT H. GLEW,* ASISH K. SAHA, SIDDHARTHA DAS,t AND ALAN T. REMALEYt Department of Microbiology, Biochemistry, and Molecular Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261 INTRODUCTION .............................................. CLINICAL MANIFESTATIONS OF LEISHMANIASIS .............................................. MORPHOLOGY AND LIFE CYCLE OF THE ORGANISM ............................................... SURFACE ENZYMES .............................................. Hydrolases .............................................. Phosphomonoesterases .............................................. (i) Phosphatases ............................................... (a) Membrane-bound acid phosphatase .............................................. (b) Secreted extracellular acid phosphatase .............................................. (ii) Nucleotidases .............................................. Proteases ............................................... Downloaded from http://mmbr.asm.org/ on December 24, 2011 by deepdyve Protein Kinases ........... METABOLISM ........... Lipids and Lipid Metabolism ........................... Energy Metabolism ........................... Glucose metabolism ........................... Fatty acid oxidation ........................... Amino acid catabolism ........................... Purine and Pyrimidine Metabolism ........................... Purines ........................... Pyrimidines ........................... EXCRETED FACTOR ........................... FUTURE WORK ........................... ACKNOWLEDGMENTS ........................... LITERATURE CITED ........................... INTRODUCTION Since 1980, there has been a burst of published reports describing the biochemistry of various human parasites. Interest