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Aß is the major component of amyloid plaques characterizing Alzheimers disease (AD). Aß accumulation can be affected by numerous factors including increased rates of production and/or impaired clearance. Insulin-degrading enzyme (IDE) has been implicated as a candidate enzyme responsible for the degradation and clearance of Aß in the brain. We have previously shown that AD patients exhibit abnormalities in insulin metabolism that are associated with apoliprotein E (APOE) status. The possible association of IDE with AD, as well as the link between APOE status and insulin metabolism, led us to examine the expression of IDE in AD. We report that hippocampal IDE protein is reduced by approximately 50% in 4+ AD patients compared to 4- patients and controls. The allele-specific decrease of IDE in 4+ AD patients is not associated with neuronal loss since neuron-specific enolase levels were comparable between the AD groups, regardless of APOE status. Hippocampal IDE mRNA levels were also reduced in AD patients with the 4 allele compared to AD and normal subjects without the 4 allele. These findings show that reduced IDE expression is associated with a significant risk factor for AD and suggest that IDE may interact with APOE status to affect Aß metabolism. Related articles in Am J Pathol: This Month in AJP Am J Pathol 2003 162: 1-2. Full Text
Reduced Hippocampal Insulin-Degrading Enzyme in Late-Onset Alzheimer's Disease Is Associated with the Apolipoprotein E-{epsilon}4 Allele
Abstract
Aß is the major component of amyloid plaques characterizing Alzheimers disease (AD). Aß accumulation can be affected by numerous factors including increased rates of production and/or impaired clearance. Insulin-degrading enzyme (IDE) has been implicated as a candidate enzyme responsible for the degradation and clearance of Aß in the brain. We have previously shown that AD patients exhibit abnormalities in insulin metabolism that are associated with apoliprotein E (APOE) status. The possible association of IDE with AD, as well as the link between APOE status and insulin metabolism, led us to examine the expression of IDE in AD. We report that hippocampal IDE protein is reduced by approximately 50% in 4+ AD patients compared to 4- patients and controls. The allele-specific decrease of IDE in 4+ AD patients is not associated with neuronal loss since neuron-specific enolase levels were comparable between the AD groups, regardless of APOE status. Hippocampal IDE mRNA levels were also reduced in AD patients with the 4 allele compared to AD and normal subjects without the 4 allele. These findings show that reduced IDE expression is associated with a significant risk factor for AD and suggest that IDE may interact with APOE status to affect Aß metabolism. Related articles in Am J Pathol: This Month in AJP Am J Pathol 2003 162: 1-2. Full Text
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Reduced Hippocampal Insulin-Degrading Enzyme in Late-Onset Alzheimer's Disease Is Associated with the Apolipoprotein E-{epsilon}4 Allele
Cook, David G.; Leverenz, James B.; McMillan, Pamela J.; Kulstad, J. Jacob; Ericksen, Sasha; Roth, Richard A.; Schellenberg, Gerard D.; Jin, Lee-Way; Kovacina, Kristina S.; Craft, Suzanne
Follow American Journal of Pathology
, Volume 162 (1): 313
American Society for Investigative Pathology – Jan 1, 2003
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