Personality in the Making
Abstract
histologically verified cases of Pickâs disease, there had been, in the early stage of the disease, social and ethical aberrations including lying, stealing, and the squandering of money. These errors of behavior were not noted in Alzheimerâs disease. The 2 diseases were indistinguishable, clinically, in their late stages. The monograph ends with the pathological findings in i8 cases of each disease. In Alzheimerâs disease the parietal as well as the frontal and temporal lobes usually showed cortical atrophy. The parietal lobes were not involved in Pickâs disease. The Alzheimer cases also showed loss of ganglion cells and other degenerative changes in the basal ganglia. Basal ganglion degeneration was found only once in the i8 cases of Pickâs disease. The additional findings of atrophy of the anterior end of the corpus callosum, (in 2 cases), and of the cerebellum, (in I case), were seen in Alzheimerâs disease. In Pickâs disease the degenerative changes were confined to the frontal and temporal cerebral cortex. In Alzheimerâs disease the degenerate cortical tissue contained numerous argentophile plaques and changes in the neurofibrils of the cortical cells. These changes were never found in Pickâs disease. Ballooning of degenerate cortical nerve cells was, on the