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Myoclonic seizures followed by grand mal seizures during clozapine treatment

Myoclonic seizures followed by grand mal seizures during clozapine treatment Myoclonic ClozapineSeizures Treatmentby GrandTo THE EDITOR: Grand mal seizures are known to occur during treatment with clozapine at a dose-dependent prevalence of up to 5% (1). HaIler and Binder (1) included a case with myoclonus in their report about clozapine and seizures. Recently, we reported three cases of generalized myoclonic seizures during clozapine treatment (2). We recently observed a case of repetitive myoclonic seizures followed by two grand mal seizures. Ms. A, 26 years old, was hospitalized during the second episode of paranoid schizophrenia. There was no indication of any preexisting seizure disorder in the patient or in her family. Physical examination, laboratory tests, and EEG were normal on admission. The patient developed disabling extrapyramidal side effects while taking three standard neuroleptics. Therefore, her medication was changed to dozapine, beginning with 50 mg/day and reaching the maximum dose of 500 mg/day within 12 weeks. The regimen of 500 mg/day of clozapine and, concomitantly, 3 mg/day of lorazepam and 0.375 mg/day of tropinbenzilatc was held stable during the following 4 weeks. The psychotic symptoms improved gradually, and no major side effects appeared until Ms. A experienced sudden, multiple, involuntary, symmetrical jerks of both shoulders and arms, which resulted in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Psychiatry American Psychiatric Publishing, Inc (Journal)

Myoclonic seizures followed by grand mal seizures during clozapine treatment

Myoclonic seizures followed by grand mal seizures during clozapine treatment

American Journal of Psychiatry , Volume 150 (7) – Jul 1, 1993

Abstract

Myoclonic ClozapineSeizures Treatmentby GrandTo THE EDITOR: Grand mal seizures are known to occur during treatment with clozapine at a dose-dependent prevalence of up to 5% (1). HaIler and Binder (1) included a case with myoclonus in their report about clozapine and seizures. Recently, we reported three cases of generalized myoclonic seizures during clozapine treatment (2). We recently observed a case of repetitive myoclonic seizures followed by two grand mal seizures. Ms. A, 26 years old, was hospitalized during the second episode of paranoid schizophrenia. There was no indication of any preexisting seizure disorder in the patient or in her family. Physical examination, laboratory tests, and EEG were normal on admission. The patient developed disabling extrapyramidal side effects while taking three standard neuroleptics. Therefore, her medication was changed to dozapine, beginning with 50 mg/day and reaching the maximum dose of 500 mg/day within 12 weeks. The regimen of 500 mg/day of clozapine and, concomitantly, 3 mg/day of lorazepam and 0.375 mg/day of tropinbenzilatc was held stable during the following 4 weeks. The psychotic symptoms improved gradually, and no major side effects appeared until Ms. A experienced sudden, multiple, involuntary, symmetrical jerks of both shoulders and arms, which resulted in

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Publisher
American Psychiatric Publishing, Inc (Journal)
Copyright
Copyright © American Psychiatric Association. All rights reserved
ISSN
0002-953X
Publisher site
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Abstract

Myoclonic ClozapineSeizures Treatmentby GrandTo THE EDITOR: Grand mal seizures are known to occur during treatment with clozapine at a dose-dependent prevalence of up to 5% (1). HaIler and Binder (1) included a case with myoclonus in their report about clozapine and seizures. Recently, we reported three cases of generalized myoclonic seizures during clozapine treatment (2). We recently observed a case of repetitive myoclonic seizures followed by two grand mal seizures. Ms. A, 26 years old, was hospitalized during the second episode of paranoid schizophrenia. There was no indication of any preexisting seizure disorder in the patient or in her family. Physical examination, laboratory tests, and EEG were normal on admission. The patient developed disabling extrapyramidal side effects while taking three standard neuroleptics. Therefore, her medication was changed to dozapine, beginning with 50 mg/day and reaching the maximum dose of 500 mg/day within 12 weeks. The regimen of 500 mg/day of clozapine and, concomitantly, 3 mg/day of lorazepam and 0.375 mg/day of tropinbenzilatc was held stable during the following 4 weeks. The psychotic symptoms improved gradually, and no major side effects appeared until Ms. A experienced sudden, multiple, involuntary, symmetrical jerks of both shoulders and arms, which resulted in

Journal

American Journal of PsychiatryAmerican Psychiatric Publishing, Inc (Journal)

Published: Jul 1, 1993

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