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LYSERGIC ACID DIETHYLAMIDE (LSD-25): A Clinical-Psychological Study

American Journal of Psychiatry , Volume 108 (12): 896 – Jun 1, 1952


Am Psychiatric Assoc
Copyright © 1952 American Psychiatric Association. All rights reserved.
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LYSERGIC ACID DIETHYLAMIDE (LSD-25): A Clinical-Psychological Study


A Clinical-Psychological Study CHARLES SAVAGE MC, USN. 1 1 The Division of Psychiatry and Neurology, Naval Medical Research Institute, Bethesda, Md. Lysergic acid diethylamide (LSD-25 Sandoz) given orally in single doses as low as 20 micrograms produces depersonalization, derealization, and increased imagery in "normal" individuals. Larger doses are required to produce the same effect in psychotic patients. Of 15 patients with depressive reactions, 3 recovered and 4 improved after one month's treatment with daily oral doses of 20-100 micrograms of LSD. Four patients showed no improvement. In 4 cases, treatment was discontinued before proper evaluation could be made. Anxiety was a prominent reaction while less frequently euphoria was observed. In 3 patients who developed euphoria it served as an aid to psychotherapy by encouraging expression of feeling. In the others the heightened anxiety encouraged reticence rather than confidence. Improvement obtained during the course of LSD therapy was not greater than that obtained without its use in comparable cases. However, LSD affords therapeutically valuable insights into unconscious processes by the medium of the hallucinations it produces.
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