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Long-Term Treatment of Hashimoto's Encephalopathy

Long-Term Treatment of Hashimoto's Encephalopathy Hashimoto’s encephalopathy (HE) has been described as an encephalopathy, with acute or subacute onset, accompanied by seizures, tremor, myoclonus, ataxia, psychosis, and stroke-like episodes, with a relapsing/remitting or progressive course. HE patients have positive antithyroid antibodies, are usually in a subclinical hypothyroid state, have elevated cerebral spinal fluid (CSF) protein, and have nonspecific electroencephalogram (EEG) and imaging abnormalities in the absence of CNS infection, tumor, or stroke. The authors present two cases of HE, demonstrating an excellent response to high dose steroids acutely followed by long-term treatment with steroids and other immunomodulatory agents. A review of the literature is also provided. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neuropsychiatry & Clinical Neurosciences American Psychiatric Publishing, Inc (Journal)

Long-Term Treatment of Hashimoto's Encephalopathy

Long-Term Treatment of Hashimoto's Encephalopathy

Journal of Neuropsychiatry & Clinical Neurosciences , Volume 18 (1): 14 – Feb 1, 2006

Abstract

Hashimoto’s encephalopathy (HE) has been described as an encephalopathy, with acute or subacute onset, accompanied by seizures, tremor, myoclonus, ataxia, psychosis, and stroke-like episodes, with a relapsing/remitting or progressive course. HE patients have positive antithyroid antibodies, are usually in a subclinical hypothyroid state, have elevated cerebral spinal fluid (CSF) protein, and have nonspecific electroencephalogram (EEG) and imaging abnormalities in the absence of CNS infection, tumor, or stroke. The authors present two cases of HE, demonstrating an excellent response to high dose steroids acutely followed by long-term treatment with steroids and other immunomodulatory agents. A review of the literature is also provided.

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Publisher
American Psychiatric Publishing, Inc (Journal)
Copyright
Copyright © 2006 American Neuropsychiatric Association. All rights reserved.
ISSN
0895-0172
DOI
10.1176/appi.neuropsych.18.1.14
Publisher site
See Article on Publisher Site

Abstract

Hashimoto’s encephalopathy (HE) has been described as an encephalopathy, with acute or subacute onset, accompanied by seizures, tremor, myoclonus, ataxia, psychosis, and stroke-like episodes, with a relapsing/remitting or progressive course. HE patients have positive antithyroid antibodies, are usually in a subclinical hypothyroid state, have elevated cerebral spinal fluid (CSF) protein, and have nonspecific electroencephalogram (EEG) and imaging abnormalities in the absence of CNS infection, tumor, or stroke. The authors present two cases of HE, demonstrating an excellent response to high dose steroids acutely followed by long-term treatment with steroids and other immunomodulatory agents. A review of the literature is also provided.

Journal

Journal of Neuropsychiatry & Clinical NeurosciencesAmerican Psychiatric Publishing, Inc (Journal)

Published: Feb 1, 2006

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