(45K):[in this window][in a new window] Studying Gene-Environment Interactions Research on how interactions between candidate genes and environmental factors influence psychiatric illnesses has generated enthusiasm but not many replicable findings. Duncan and Keller (p. 1041) discovered that the more closely a replication study matched the original research, the less likely it was to have similar results. Publication bias toward positive findings was apparent both in reports of novel findings and in replication studies. Another contributor to false discoveries in many studies of candidate genes is low statistical power due to small study groups or other design factors.Antipsychotics for Anxiety Disorders Prescription of antipsychotic medications during visits for anxiety disorders doubled between 1996 and 2007 among office-based psychiatrists, from 10.6% to 21.3% of visits. The nationwide data analyzed by Comer et al. (CME, p. 1057) demonstrate increases for comorbid FDA-approved indications, such as bipolar disorder, and for nonapproved indications. The greatest increase was among patients with panic disorder or agoraphobia. In an editorial, Breier (p. 1012) considers whether these findings indicate an unmet need for treatments for refractory anxiety disorders.Brain Structure and Functioning Related in Late-Life Depression The difference in brain activation during emotional processing between elderly patients with
In This Issue
Abstract
(45K):[in this window][in a new window] Studying Gene-Environment Interactions Research on how interactions between candidate genes and environmental factors influence psychiatric illnesses has generated enthusiasm but not many replicable findings. Duncan and Keller (p. 1041) discovered that the more closely a replication study matched the original research, the less likely it was to have similar results. Publication bias toward positive findings was apparent both in reports of novel findings and in replication studies. Another contributor to false discoveries in many studies of candidate genes is low statistical power due to small study groups or other design factors.Antipsychotics for Anxiety Disorders Prescription of antipsychotic medications during visits for anxiety disorders doubled between 1996 and 2007 among office-based psychiatrists, from 10.6% to 21.3% of visits. The nationwide data analyzed by Comer et al. (CME, p. 1057) demonstrate increases for comorbid FDA-approved indications, such as bipolar disorder, and for nonapproved indications. The greatest increase was among patients with panic disorder or agoraphobia. In an editorial, Breier (p. 1012) considers whether these findings indicate an unmet need for treatments for refractory anxiety disorders.Brain Structure and Functioning Related in Late-Life Depression The difference in brain activation during emotional processing between elderly patients with
Loading next page...
If you're having problem loading pages
Try our single-page mode to load one page at a time
Preview Only. This article cannot be rented because we do not currently have permission from the publisher.
/lp/american-psychiatric-publishing-inc-journal/in-this-issue-fZgBekW0Yb
Welcome to DeepDyve! Rent Premier Research Articles and Save Up to 90%
Preview Only
In This Issue
Follow American Journal of Psychiatry
, Volume 168 (10): A34
American Psychiatric Publishing, Inc (Journal) – Oct 1, 2011
More Info
More Like This Article
View All dataSource[]=actageo&dataSource[]=aspet&dataSource[]=aaos&dataSource[]=aacc&dataSource[]=aacr&dataSource[]=aea&dataSource[]=aip&dataSource[]=ajnr&dataSource[]=ams&dataSource[]=aps_physical&dataSource[]=appi_book&dataSource[]=appi_journal&dataSource[]=apha&dataSource[]=asip&dataSource[]=asm&dataSource[]=asn&dataSource[]=aspb&dataSource[]=avs&dataSource[]=annual_reviews&dataSource[]=arxiv&dataSource[]=acm&dataSource[]=berghahn&dataSource[]=cabi&dataSource[]=clinical_trials&dataSource[]=dailymed&dataSource[]=degruyter&dataSource[]=du_press&dataSource[]=esa&dataSource[]=eu_press&dataSource[]=elsevier&dataSource[]=emerald&dataSource[]=ejtr&dataSource[]=emea&dataSource[]=epo&dataSource[]=faseb&dataSource[]=gsa&dataSource[]=health_affairs&dataSource[]=hindawi&dataSource[]=imanager&dataSource[]=imedpub&dataSource[]=informa_healthcare&dataSource[]=informs&dataSource[]=iop&dataSource[]=iucr&dataSource[]=iospress&dataSource[]=jbjs&dataSource[]=leftcoast&dataSource[]=lu_press&dataSource[]=mesharpe&dataSource[]=mary_ann_liebert&dataSource[]=medline&dataSource[]=mit_press&dataSource[]=nature&dataSource[]=oxford&dataSource[]=pier_professional&dataSource[]=pnas&dataSource[]=portlandpress&dataSource[]=psyc_articles&dataSource[]=psyc_books&dataSource[]=psyc_critiques&dataSource[]=plos_journal&dataSource[]=pubmed_central&dataSource[]=rsna&dataSource[]=rockefeller&dataSource[]=rcn&dataSource[]=ria&dataSource[]=rsc&dataSource[]=sage&dataSource[]=spie&dataSource[]=springer_journal&dataSource[]=springer&dataSource[]=taylor_francis&dataSource[]=aps&dataSource[]=the_scientist&dataSource[]=uc_press&dataSource[]=uspto_abstract&dataSource[]=wiley&dataSource[]=pct
© 2012 DeepDyve, Inc. All rights reserved.
Terms of Service | Privacy Policy
