Dept. of Psychiatry, Indira Gandhi Medical College, Himachal Pradesh, India e-mail: drashish1980{at}yahoo.com.in To the Editor: Antidepressant-induced manic switch is generally seen in patients with risk factors for bipolar disorder. To the contrary, the authors hereby report a case of an adolescent boy who developed fluoxetine-induced hypomania but did not have any risk factor for bipolarity. Hypomania might be a genuine side effect associated with antidepressants like fluoxetine Literature suggests that antidepressants can precipitate mania in patients with unipolar/bipolar disorder.1 During the pre-drug era, spontaneous mild depression after a manic episode and spontaneous hypomania after a melancholic episode were common, and had no bearing on the primary diagnosis.2 Previous reports of fluoxetine-induced mania/hypomania have been mostly in patients with depression.3,4 It can be argued that these cases had natural manic episodes of bipolar disorder. On the contrary, fluoxetine has been argued to be useful in bipolar II disorder.5 We hereby report a case of an adolescent boy who developed hypomania while on fluoxetine without any risk factor for manic switch.Case Report A 17-year-old boy was suffering from tension-type headache along with mild episodic anxiety symptoms. His past, family, and personal history were nonsignificant. There was no history to suggest
Hypomania as a Genuine Side Effect of Fluoxetine
Abstract
Dept. of Psychiatry, Indira Gandhi Medical College, Himachal Pradesh, India e-mail: drashish1980{at}yahoo.com.in To the Editor: Antidepressant-induced manic switch is generally seen in patients with risk factors for bipolar disorder. To the contrary, the authors hereby report a case of an adolescent boy who developed fluoxetine-induced hypomania but did not have any risk factor for bipolarity. Hypomania might be a genuine side effect associated with antidepressants like fluoxetine Literature suggests that antidepressants can precipitate mania in patients with unipolar/bipolar disorder.1 During the pre-drug era, spontaneous mild depression after a manic episode and spontaneous hypomania after a melancholic episode were common, and had no bearing on the primary diagnosis.2 Previous reports of fluoxetine-induced mania/hypomania have been mostly in patients with depression.3,4 It can be argued that these cases had natural manic episodes of bipolar disorder. On the contrary, fluoxetine has been argued to be useful in bipolar II disorder.5 We hereby report a case of an adolescent boy who developed hypomania while on fluoxetine without any risk factor for manic switch.Case Report A 17-year-old boy was suffering from tension-type headache along with mild episodic anxiety symptoms. His past, family, and personal history were nonsignificant. There was no history to suggest
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Hypomania as a Genuine Side Effect of Fluoxetine
Aggarwal, Ashish; Sharma, Dinesh Dutt; Sharma, Ravi Chand; Kumar, Ramesh
Follow Journal of Neuropsychiatry & Clinical Neurosciences
, Volume 23 (3): E23
American Psychiatric Publishing, Inc (Journal) – Aug 1, 2011
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