TO THE EDITOR: Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder without identifiable evidence of structural or biochemical abnormalities.1 Although there is evidence that an abnormality in brain–gut signaling or serotonin metabolism plays a role in IBS,2 its pathophysiology remains uncertain. Here, we report on a case of IBS comorbid with major depressive disorder (MDD) whose clinical presentations of IBS were effectively treated with bupropion, an antidepressant that inhibits the reuptake of dopamine and noradrenaline (norepinephrine), but not of serotonin. Case Report "Mr. W," an 83-year-old man with a history of MDD, had suffered from severe lower abdominal distension, flatulence, and constipation followed by diarrhea for more than 30 years. His gastroenterologist made the diagnosis of IBS according to the diagnostic criteria in ICD–9, and treated him with dioctahedral smectite (9 gm/day), lactomin (1,200 mg/day), mebeverine (300 mg/day), metoclopramide (15 mg/day), and normacol-plus granules (14 gm/day), with minimal improvement. His gastroenterologist referred Mr. W to Psychiatry for an evaluation of depression; he described loss of interest, decreased appetite, difficulty falling asleep, difficulty staying asleep, early-morning awakening, feelings of guilt, hopelessness, helplessness, worthlessness, and thoughts about death. These symptoms had persisted for more than 6 months, and
Efficacy of Bupropion for Irritable Bowel Syndrome
Abstract
TO THE EDITOR: Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder without identifiable evidence of structural or biochemical abnormalities.1 Although there is evidence that an abnormality in brain–gut signaling or serotonin metabolism plays a role in IBS,2 its pathophysiology remains uncertain. Here, we report on a case of IBS comorbid with major depressive disorder (MDD) whose clinical presentations of IBS were effectively treated with bupropion, an antidepressant that inhibits the reuptake of dopamine and noradrenaline (norepinephrine), but not of serotonin. Case Report "Mr. W," an 83-year-old man with a history of MDD, had suffered from severe lower abdominal distension, flatulence, and constipation followed by diarrhea for more than 30 years. His gastroenterologist made the diagnosis of IBS according to the diagnostic criteria in ICD–9, and treated him with dioctahedral smectite (9 gm/day), lactomin (1,200 mg/day), mebeverine (300 mg/day), metoclopramide (15 mg/day), and normacol-plus granules (14 gm/day), with minimal improvement. His gastroenterologist referred Mr. W to Psychiatry for an evaluation of depression; he described loss of interest, decreased appetite, difficulty falling asleep, difficulty staying asleep, early-morning awakening, feelings of guilt, hopelessness, helplessness, worthlessness, and thoughts about death. These symptoms had persisted for more than 6 months, and
Loading next page...
If you're having problem loading pages
Try our single-page mode to load one page at a time
Preview Only. This article cannot be rented because we do not currently have permission from the publisher.
/lp/american-psychiatric-publishing-inc-journal/efficacy-of-bupropion-for-irritable-bowel-syndrome-pm90VRzIlR
Welcome to DeepDyve! Rent Premier Research Articles and Save Up to 90%
Preview Only
Efficacy of Bupropion for Irritable Bowel Syndrome
Liou, Dr. Kai-Jen Cheng
Follow Psychosomatics
, Volume 51 (6): 536
American Psychiatric Publishing, Inc (Journal) – Nov 1, 2010
More Info
More Like This Article
View All dataSource[]=actageo&dataSource[]=aspet&dataSource[]=aaos&dataSource[]=aacc&dataSource[]=aacr&dataSource[]=aea&dataSource[]=aip&dataSource[]=ajnr&dataSource[]=ams&dataSource[]=aps_physical&dataSource[]=appi_book&dataSource[]=appi_journal&dataSource[]=apha&dataSource[]=asip&dataSource[]=asm&dataSource[]=asn&dataSource[]=aspb&dataSource[]=avs&dataSource[]=annual_reviews&dataSource[]=arxiv&dataSource[]=acm&dataSource[]=berghahn&dataSource[]=cabi&dataSource[]=clinical_trials&dataSource[]=dailymed&dataSource[]=degruyter&dataSource[]=du_press&dataSource[]=esa&dataSource[]=eu_press&dataSource[]=elsevier&dataSource[]=emerald&dataSource[]=ejtr&dataSource[]=emea&dataSource[]=epo&dataSource[]=faseb&dataSource[]=gsa&dataSource[]=health_affairs&dataSource[]=hindawi&dataSource[]=imanager&dataSource[]=imedpub&dataSource[]=informa_healthcare&dataSource[]=informs&dataSource[]=iop&dataSource[]=iucr&dataSource[]=iospress&dataSource[]=jbjs&dataSource[]=leftcoast&dataSource[]=lu_press&dataSource[]=mesharpe&dataSource[]=mary_ann_liebert&dataSource[]=medline&dataSource[]=mit_press&dataSource[]=nature&dataSource[]=oxford&dataSource[]=pier_professional&dataSource[]=pnas&dataSource[]=portlandpress&dataSource[]=psyc_articles&dataSource[]=psyc_books&dataSource[]=psyc_critiques&dataSource[]=plos_journal&dataSource[]=pubmed_central&dataSource[]=rsna&dataSource[]=rockefeller&dataSource[]=rcn&dataSource[]=ria&dataSource[]=rsc&dataSource[]=sage&dataSource[]=spie&dataSource[]=springer_journal&dataSource[]=springer&dataSource[]=taylor_francis&dataSource[]=aps&dataSource[]=the_scientist&dataSource[]=uc_press&dataSource[]=uspto_abstract&dataSource[]=wiley&dataSource[]=pct
© 2012 DeepDyve, Inc. All rights reserved.
Terms of Service | Privacy Policy
