Abstract

to pin prick neurological treatedor other stimuli. findings were with Aspirin,nega-I.M.sodium amytal, and I.V. fluids. She was also covered with a wet sheet upon which 2 fans were directed. In 4 hours the temperature came down to 100.5#{176}F., the convulsions stopped and patient started to respond. After 12 hours her temperature was down to 99#{176} her pupils F., were still somewhat dilated and did not react to light until 48 hours later. Laboratory studies of urinalysis and CBC, on admission and on 2 consecutive days after the reaction, were within normal limits. An EEC taken 2 days following the reaction, was normal.it is difficult to ascertain if the reaction (a) was due purely to Tofranil which, though an energizer, has a chemical structure similar to phenothiazines, (b) if it was due to synergetic action of Tofr#{227}nilsynergetically,and Nardil (monoamine oxidase inhibitor) or (c) if it was due to any idiosyncrasy on the part of the patient. Two years ago we had another patient who developed a similar reaction to a combination of Pacatal and Sparine (both phenothiazines). The case was not reported.The present case is and need being reported invarious emphasize thistranquilizers theenergizers of furtherand researchto inSince variousit is