Abstract
Sexual dysfunction is a very common and distressing problem caused by diverse physical, psychological, lifestyle, and medication-related factors. When men and women seek treatment for sexual dysfunction at any age but particularly at midlife and beyond, what medications, hormonal and nutritional factors should the clinician consider and why? When a patient presents with a sexual problem, the clinician first must attempt to determine the specific nature of the problem and its potential cause(s). Is the patient taking any of the numerous medications that may contribute to sexual dysfunction, such as antihypertensives, mood stabilizers, antidepressants, birth control pills, antipsychotics, cytotoxic agents, nonsteroidal anti-inflammatory medications, hormones, and antihistamines? Does the patient have a history of psychiatric illness or any medical conditions that may play a role, including hormonal imbalances and nutritional deficiencies? Below I review some of the evidence for sexual dysfunction related to hormonal and micronutrient deficiencies and discuss the potential relevance of hormone replacement and micronutrient supplementation. Much has been written about the sexual side effects of the widely used selective serotonin reuptake inhibitor (SSRI) antidepressants (1). They cause sexual dysfunction through several mechanisms, including inhibition of cholinergic activity, inhibition of nitric oxide synthetase, reduction of dopaminergic activity,Preview Only. This article cannot be rented because we do not currently have permission from the publisher.
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