Subscribe to thousands of academic journals for just $40/month
Read and share the articles you need for your research, all in one place.

Amisulpride Augmentation of Clozapine in Refractory Schizophrenia

Details

Publisher
Am Neuropsych Assoc
Copyright
Copyright © 2011 American Neuropsychiatric Association. All rights reserved.
ISSN
0895-0172
eISSN
1545-7222
D.O.I.
10.1176/appi.neuropsych.23.3.E15
Publisher site
See Article on Publisher Site

Preview Only

Expand Tray Hide Tray

Amisulpride Augmentation of Clozapine in Refractory Schizophrenia

Abstract

Department of Psychiatry, Beitou Armed Forces Hospital, 60, Xinmin Rd., Beitou Dist., Taipei 112, Taiwan. e-mail address: siskoala{at}gmail.com (Ms. Chiu), drhuangsd{at}hotmail.com (Dr. Huang) To the Editor: Clozapine, an atypical antipsychotic drug, is the first-choice medication for treatment-refractory schizophrenia. However, clozapine can cause some adverse effects, such as agranulocytosis and sialorrhea, making it difficult for patients to continue with treatment. Otherwise, treatment options for patients who are resistant to clozapine are extremely limited. Herein, the authors report the case of a patient with refractory schizophrenia treated by amisulpride augmentation of clozapine who got significant improvement not only in his positive and negative symptoms but also the side effect of salivation. This case report might provide an alternative treatment for refractory schizophrenia.Case Report A 53-year-old man with chronic, refractory schizophrenia was hospitalized because of his symptoms of hostility, aggression, insomnia, delusions, and auditory hallucinations, despite his medication with clozapine 200 mg per day. His initial laboratory studies revealed no remarkable findings. Clozapine was titrated to 350 mg per day for marked psychotic symptoms, but it seemed to be only slightly effective. Meanwhile, he complained of salivation worsening and wanted to discontinue clozapine treatment because of this adverse effect. We then
Loading next page...

Preview Only. This article cannot be rented because we do not currently have permission from the publisher.

 
/lp/american-psychiatric-publishing-inc-journal/amisulpride-augmentation-of-clozapine-in-refractory-schizophrenia-HlcGRxhGCL