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Age-Related Prognostic Factors in the Severity of Illness of Tourette's Syndrome in Monozygotic Twins

Age-Related Prognostic Factors in the Severity of Illness of Tourette's Syndrome in Monozygotic Twins


Thomas M. Hyde M.D., Ph.D. 1 , Eric K. Fitzcharles B.S. 1 , and Daniel R. Weinberger M.D. 1 1 Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, Washington, DC. Tourette's syndrome (TS) was studied in 18 pairs of monozygotic twins where at least one member of the twin set had TS. Sixteen twin sets were concordant for motor tics and had different ages of onset of motor tics (as reported by the mothers and/or medical records). Among these pairs, the earlier motor ticquer was more likely to have a more severe course of illness as assayed by two different indices. In the 10 sets concordant for vocal tics, the earlier vocal ticquer had a more severe course as assayed by only one index. The authors conclude that an early age of onset of motor tics may be the strongest predictor of a more severe life-time course of a tic disorder. Submitted on April 30, 1992 Revised on November 13, 1992 Accepted on November 20, 1992
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